The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study
Introduction Theory of Mind is the ability to attribute mental states to others. Investigations have distinguished implicit and explicit forms of ToM. It is known, that patients with schizoprenia have deficits in their explicit ToM, and they also show altered brain activations during examining expl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822005223/type/journal_article |
| _version_ | 1827754465737834496 |
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| author | E. Varga T. Bugya A. Hajnal T. Tényi R. Herold |
| author_facet | E. Varga T. Bugya A. Hajnal T. Tényi R. Herold |
| author_sort | E. Varga |
| collection | DOAJ |
| description |
Introduction
Theory of Mind is the ability to attribute mental states to others. Investigations have distinguished implicit and explicit forms of ToM. It is known, that patients with schizoprenia have deficits in their explicit ToM, and they also show altered brain activations during examining explicit ToM.
Objectives
In this study our aim was to investigate the underlying neural substrates of implicit ToM in patients with schizophrenia with fMRI.
Methods
Seven healthy subjects and two patients with first episode schizophrenia were involved. We used: false belief condition and control condition. All movies consisted of a belief formation phase and an outcome phase. The belief formation phase started with an agent placing a ball on a table in front of an occluder. Then the ball rolled behind the occluder. The movies could continue in different ways leading to a true or false belief. At the end of each movie, the agent reentered the scene and the occluder was lowered. In the outcome phase the ball was either present or absent behind the occluder. The control conditions started with a ball rolled behind the occluder on a table ended up with two different ways as the ball was either present or absent behind the occluder. There was no agent in the control movies.
Results
We found that healthy subjects activated significantly stronger the left lingual gyrus as well as the right temporoparietal junction.
Conclusions
Our findings suggest deficits in implicit ToM in schizophrenia and our findings also might help to clarify the underlying neural substrates of implicit ToM.
Disclosure
This research project was supported by the KTIA-13-NAP-A-II/12 (2018–2022) and the Hungarian National Excellence Centrum Grant 2018–2019.
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| first_indexed | 2024-03-11T07:50:42Z |
| format | Article |
| id | doaj.art-9bfb77191a5c44319f3c394c0b8ae40a |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:50:42Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-9bfb77191a5c44319f3c394c0b8ae40a2023-11-17T05:06:53ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S199S19910.1192/j.eurpsy.2022.522The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI studyE. Varga0T. Bugya1A. Hajnal2T. Tényi3R. Herold4University of Pécs, Medical School, Department Of Pediatrics, Pécs, HungaryUniversity of Pécs, Department Of Cartography And Geoinformatics, Pécs, HungaryUniversity of Pécs, Department Of Psychiatry And Psychotherapy, Pécs, HungaryUniversity of Pécs, Department Of Psychiatry And Psychotherapy, Pécs, HungaryUniversity of Pécs, Department Of Psychiatry And Psychotherapy, Pécs, Hungary Introduction Theory of Mind is the ability to attribute mental states to others. Investigations have distinguished implicit and explicit forms of ToM. It is known, that patients with schizoprenia have deficits in their explicit ToM, and they also show altered brain activations during examining explicit ToM. Objectives In this study our aim was to investigate the underlying neural substrates of implicit ToM in patients with schizophrenia with fMRI. Methods Seven healthy subjects and two patients with first episode schizophrenia were involved. We used: false belief condition and control condition. All movies consisted of a belief formation phase and an outcome phase. The belief formation phase started with an agent placing a ball on a table in front of an occluder. Then the ball rolled behind the occluder. The movies could continue in different ways leading to a true or false belief. At the end of each movie, the agent reentered the scene and the occluder was lowered. In the outcome phase the ball was either present or absent behind the occluder. The control conditions started with a ball rolled behind the occluder on a table ended up with two different ways as the ball was either present or absent behind the occluder. There was no agent in the control movies. Results We found that healthy subjects activated significantly stronger the left lingual gyrus as well as the right temporoparietal junction. Conclusions Our findings suggest deficits in implicit ToM in schizophrenia and our findings also might help to clarify the underlying neural substrates of implicit ToM. Disclosure This research project was supported by the KTIA-13-NAP-A-II/12 (2018–2022) and the Hungarian National Excellence Centrum Grant 2018–2019. https://www.cambridge.org/core/product/identifier/S0924933822005223/type/journal_articleschizophréniaNeuroimagingTheory of MindfMRI |
| spellingShingle | E. Varga T. Bugya A. Hajnal T. Tényi R. Herold The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study European Psychiatry schizophrénia Neuroimaging Theory of Mind fMRI |
| title | The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study |
| title_full | The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study |
| title_fullStr | The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study |
| title_full_unstemmed | The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study |
| title_short | The investigation of implicit Theory of Mind in patients with schizophrenia – a whole brain fMRI study |
| title_sort | investigation of implicit theory of mind in patients with schizophrenia a whole brain fmri study |
| topic | schizophrénia Neuroimaging Theory of Mind fMRI |
| url | https://www.cambridge.org/core/product/identifier/S0924933822005223/type/journal_article |
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