Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex
Abstract The main purpose of this work was to compare the effects of the four preparation methods on the TFLX/HP-β-CD inclusion complex. The effects of different preparation methods on the inclusion complex were investigated by SEM, DSC, PXRD, FT-IR and 1H NMR. All the characterization information i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100854&tlng=en |
| _version_ | 1828068196128653312 |
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| author | Jianfei Sun Hailong Hong Ning Zhu Limin Han Quanling Suo |
| author_facet | Jianfei Sun Hailong Hong Ning Zhu Limin Han Quanling Suo |
| author_sort | Jianfei Sun |
| collection | DOAJ |
| description | Abstract The main purpose of this work was to compare the effects of the four preparation methods on the TFLX/HP-β-CD inclusion complex. The effects of different preparation methods on the inclusion complex were investigated by SEM, DSC, PXRD, FT-IR and 1H NMR. All the characterization information indicated that the four preparation methods could cause interaction between TFLX and HP-β-CD, but the inclusion complex prepared by solvent evaporation has more reaction sites. Phase solubility experiments demonstrated that the inclusion reaction was spontaneous. In vitro dissolution experiments showed that the dissolution of the inclusion complex in water was: solvent evaporation method (64.39%) > grinding method (42.37%) > ultrasonic method (40.00%) > freezing method (36.08%), and all higher than pure TFLX and physical mixture. These results suggest that the solvent evaporation is the most suitable method for preparing TFLX/HP-β-CD inclusion complexes. |
| first_indexed | 2024-04-10T23:59:08Z |
| format | Article |
| id | doaj.art-9bfc6bee3bd84226945d9459a43e0525 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T23:59:08Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-9bfc6bee3bd84226945d9459a43e05252023-01-10T07:35:54ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e18650Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complexJianfei Sunhttps://orcid.org/0000-0001-8126-4988Hailong Honghttps://orcid.org/0000-0002-7533-4115Ning Zhuhttps://orcid.org/0000-0002-7535-1310Limin HanQuanling SuoAbstract The main purpose of this work was to compare the effects of the four preparation methods on the TFLX/HP-β-CD inclusion complex. The effects of different preparation methods on the inclusion complex were investigated by SEM, DSC, PXRD, FT-IR and 1H NMR. All the characterization information indicated that the four preparation methods could cause interaction between TFLX and HP-β-CD, but the inclusion complex prepared by solvent evaporation has more reaction sites. Phase solubility experiments demonstrated that the inclusion reaction was spontaneous. In vitro dissolution experiments showed that the dissolution of the inclusion complex in water was: solvent evaporation method (64.39%) > grinding method (42.37%) > ultrasonic method (40.00%) > freezing method (36.08%), and all higher than pure TFLX and physical mixture. These results suggest that the solvent evaporation is the most suitable method for preparing TFLX/HP-β-CD inclusion complexes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100854&tlng=enTosufloxacin tosylateHydroxypropyl-β-cyclodextrinMethodsInclusion complex |
| spellingShingle | Jianfei Sun Hailong Hong Ning Zhu Limin Han Quanling Suo Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex Brazilian Journal of Pharmaceutical Sciences Tosufloxacin tosylate Hydroxypropyl-β-cyclodextrin Methods Inclusion complex |
| title | Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex |
| title_full | Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex |
| title_fullStr | Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex |
| title_full_unstemmed | Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex |
| title_short | Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex |
| title_sort | effect of preparation methods on tosufloxacin tosylate hydroxypropyl β cyclodextrin inclusion complex |
| topic | Tosufloxacin tosylate Hydroxypropyl-β-cyclodextrin Methods Inclusion complex |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100854&tlng=en |
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