Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.

Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.

Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of the affected cell. Different molecules were described as disrupting this cell structure and thus showing antitumor activity. We have previously defined that elisidepsin (Irvalec®, PM02734) in...

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Bibliographic Details
Main Authors: José Manuel Molina-Guijarro, Carolina García, Álvaro Macías, Luis Francisco García-Fernández, Cristina Moreno, Fernando Reyes, Juan Fernando Martínez-Leal, Rogelio Fernández, Valentín Martínez, Carmen Valenzuela, M Pilar Lillo, Carlos M Galmarini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608773?pdf=render

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