Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
Introduction: In Bipolar disorder the mood of the patients fluctuates between depression and mania. The main objective of the study was to find out the commonest mood stabilizers used for the treatment of Bipolar affective disorders in Western Nepal in hospitalized patients in an actual clinical...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4524/8661_CE[Ra1]_F(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
| Summary: | Introduction: In Bipolar disorder the mood of the patients
fluctuates between depression and mania. The main objective of
the study was to find out the commonest mood stabilizers used
for the treatment of Bipolar affective disorders in Western Nepal in
hospitalized patients in an actual clinical set up.
Methods: This was a cross-sectional study which was conducted
between October 2009 and September 2010 at Psychiatric ward
at Manipal teaching hospital, Pokhara, Nepal, a tertiary care
hospital situated in Western Nepal. The diagnosis of the disease
was based on ICD-10 (Tenth revision) Classification of mental
and Behavioural disorders, Diagnostic Criteria for Research. We
calculated odds ratio and their 95% confidence intervals (95%
CI). p< 0.05 was considered as statistically significant.
Results: 62.1% of the patients were less than 40 yrs, 56.3%
were male, 72.4% were unemployed and 75.9% of the patients
were having monthly income <10,000/month. As far as ethnicity
is concerned 37.9% of the cases were Brahmin and by
occupation 29.9% of the patients were students followed by
housewife 25.3%, labour 17.2%, retired 13.8% respectively.
Drugs and Psychotherapy [OR 1.4, 95% (CI 0.575, 3.4017)] was
prescribed in age <40 years as compared to age>40 yrs. Male
patients [OR 7.22, 95% (CI 0.862, 60.499)] and [OR 2.353, 95%
(CI 0.857, 6.455)] received drugs by trade names and drugs not
from the national drug list of Nepal as compared to females.
Monthly income <10,000/month and [OR 2.8, 95% (CI 0.742,
10.56)] tendency of receiving drugs by trade names. Among the
mood elevators Sodium valproate was the commonest drug to
be prescribed in 51/87(58.6%) patients followed by Lithium in
30/87 (34.5%) cases and Carbamazepine in 6/87 (6.9%) cases.
Sodium valproate was prescribed at 1,000 mg/day, Lithium was
prescribed at 900 mg/day in and Carbamazepine was prescribed
at 800 mg/day.
Conclusion: Among all the mood elevators Sodium valproate
is the commonest drug prescribed for the treatment of bipolar
affective disorder, recommended that there is a trend of using
newer drugs like sodium valproate rather than the conventional
mood stabilizers like Lithium for bipolar affective disorder in
Western Development region of Nepal. |
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| ISSN: | 2249-782X 0973-709X |