Butyrate Protects Barrier Integrity and Suppresses Immune Activation in a Caco-2/PBMC Co-Culture Model While HDAC Inhibition Mimics Butyrate in Restoring Cytokine-Induced Barrier Disruption

Butyrate Protects Barrier Integrity and Suppresses Immune Activation in a Caco-2/PBMC Co-Culture Model While HDAC Inhibition Mimics Butyrate in Restoring Cytokine-Induced Barrier Disruption

Low-grade inflammation and barrier disruption are increasingly acknowledged for their association with non-communicable diseases (NCDs). Short chain fatty acids (SCFAs), especially butyrate, could be a potential treatment because of their combined anti-inflammatory and barrier- protective capacities...

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Bibliographic Details
Main Authors: Sandra G. P. J. Korsten, Herman Vromans, Johan Garssen, Linette E. M. Willemsen
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Nutrients
Subjects:
butyrate
short chain fatty acids
intestinal epithelial cells
PBMCs
mucosal immunity
in vitro models
Online Access:https://www.mdpi.com/2072-6643/15/12/2760

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