Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy
Increasing prevalence and incidence of diabetes mellitus(DM)-the most common chronic consumptive disease worldwide-has a devastating impact on people's daily lives, particularly through the deterioration or complete loss of vision brought on by diabetic retinopathy(DR). Therefore, it is imperat...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-08-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/8/202308011.pdf |
| _version_ | 1797773023313395712 |
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| author | Hua Zou Zhi-Peng You Xiao-Jian Wu |
| author_facet | Hua Zou Zhi-Peng You Xiao-Jian Wu |
| author_sort | Hua Zou |
| collection | DOAJ |
| description | Increasing prevalence and incidence of diabetes mellitus(DM)-the most common chronic consumptive disease worldwide-has a devastating impact on people's daily lives, particularly through the deterioration or complete loss of vision brought on by diabetic retinopathy(DR). Therefore, it is imperative to investigate the pathogenesis and effective treatment of DR. Meanwhile, Pueraria lobata is the extensively used dried root of kudzu or dried kudzu, also known as Pueraria flavonoids. Moreover, its roots are primarily composed of isoflavones, Pueroside ABC, triterpenes, and alkaloids, which can calm cardio-cerebrovascular smooth muscle and enhance microcirculation. Currently, it is widely employed for the treatment of cardio-cerebrovascular diseases, osteonecrosis, DM and its complications, neurodegenerative disorders, endometriosis and tumor diseases. Inhibiting retinal neovascularization, alleviating ischemia and hypoxia, decreasing advanced glycation end products in diabetes, raising insulin-like growth factor(IGF)expression while decreasing tumor necrosis factor-α(TNF-a)expression, decreasing vascular endothelial growth factor(VEGF)expression, reducing retinal nerve cell death, inhibiting the NOD-like receptor protein 3(NLRP3)inflammatory pathway and inhibiting ferroptosis are all mechanisms by which puerarin(Pue)has been found to protect the retina in recent studies. Thus, this article summarizes the current comprehension of the mechanism and protective effect of Pue on diabetic retina, serving as a guidepost for its future development and application. |
| first_indexed | 2024-03-12T22:00:14Z |
| format | Article |
| id | doaj.art-9bffbdcfe5454c0182f830dc3d5c5f99 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-12T22:00:14Z |
| publishDate | 2023-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-9bffbdcfe5454c0182f830dc3d5c5f992023-07-25T08:31:59ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-08-012381295129810.3980/j.issn.1672-5123.2023.8.11202308011Research progress on the protective effect and mechanism of puerarin on diabetic retinopathyHua Zou0Zhi-Peng You1Xiao-Jian Wu2Nanchang University, Nanchang 330006, Jiangxi Province, China; Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaAffiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaNanchang University, Nanchang 330006, Jiangxi Province, China; Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaIncreasing prevalence and incidence of diabetes mellitus(DM)-the most common chronic consumptive disease worldwide-has a devastating impact on people's daily lives, particularly through the deterioration or complete loss of vision brought on by diabetic retinopathy(DR). Therefore, it is imperative to investigate the pathogenesis and effective treatment of DR. Meanwhile, Pueraria lobata is the extensively used dried root of kudzu or dried kudzu, also known as Pueraria flavonoids. Moreover, its roots are primarily composed of isoflavones, Pueroside ABC, triterpenes, and alkaloids, which can calm cardio-cerebrovascular smooth muscle and enhance microcirculation. Currently, it is widely employed for the treatment of cardio-cerebrovascular diseases, osteonecrosis, DM and its complications, neurodegenerative disorders, endometriosis and tumor diseases. Inhibiting retinal neovascularization, alleviating ischemia and hypoxia, decreasing advanced glycation end products in diabetes, raising insulin-like growth factor(IGF)expression while decreasing tumor necrosis factor-α(TNF-a)expression, decreasing vascular endothelial growth factor(VEGF)expression, reducing retinal nerve cell death, inhibiting the NOD-like receptor protein 3(NLRP3)inflammatory pathway and inhibiting ferroptosis are all mechanisms by which puerarin(Pue)has been found to protect the retina in recent studies. Thus, this article summarizes the current comprehension of the mechanism and protective effect of Pue on diabetic retina, serving as a guidepost for its future development and application.http://ies.ijo.cn/cn_publish/2023/8/202308011.pdfpuerarindiabetic retinopathytherapeutic methodprogress |
| spellingShingle | Hua Zou Zhi-Peng You Xiao-Jian Wu Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy Guoji Yanke Zazhi puerarin diabetic retinopathy therapeutic method progress |
| title | Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| title_full | Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| title_fullStr | Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| title_full_unstemmed | Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| title_short | Research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| title_sort | research progress on the protective effect and mechanism of puerarin on diabetic retinopathy |
| topic | puerarin diabetic retinopathy therapeutic method progress |
| url | http://ies.ijo.cn/cn_publish/2023/8/202308011.pdf |
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