Biomedical Applications of Polymeric Cryogels
The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of bioc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/9/3/553 |
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| author | Monireh Bakhshpour Neslihan Idil Işık Perçin Adil Denizli |
| author_facet | Monireh Bakhshpour Neslihan Idil Işık Perçin Adil Denizli |
| author_sort | Monireh Bakhshpour |
| collection | DOAJ |
| description | The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of biochromatography and related biomedical applications. These matrices nearly mimic the three-dimensional structure of native tissue extracellular matrix. In addition, mechanical, osmotic and chemical stability of cryogels make them attractive polymeric materials for the construction of scaffolds in tissue engineering applications and in vitro cell culture, separation materials for many different processes such as immobilization of biomolecules, capturing of target molecules, and controlled drug delivery. The low mass transfer resistance of cryogel matrices makes them useful in chromatographic applications with the immobilization of different affinity ligands to these materials. Cryogels have been introduced as gel matrices prepared using partially frozen monomer or polymer solutions at temperature below zero. These materials can be produced with different shapes and are of interest in the therapeutic area. This review highlights the recent advances in cryogelation technologies by emphasizing their biomedical applications to supply an overview of their rising stars day to day. |
| first_indexed | 2024-04-14T00:03:14Z |
| format | Article |
| id | doaj.art-9bffdbdca9c049f6abe369d4e19c87fe |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-14T00:03:14Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9bffdbdca9c049f6abe369d4e19c87fe2022-12-22T02:23:37ZengMDPI AGApplied Sciences2076-34172019-02-019355310.3390/app9030553app9030553Biomedical Applications of Polymeric CryogelsMonireh Bakhshpour0Neslihan Idil1Işık Perçin2Adil Denizli3Department of Chemistry, Faculty of Science, Hacettepe University, Ankara 06800, TurkeyDepartment of Biology, Faculty of Science, Hacettepe University, Ankara 06800, TurkeyDepartment of Biology, Faculty of Science, Hacettepe University, Ankara 06800, TurkeyDepartment of Chemistry, Faculty of Science, Hacettepe University, Ankara 06800, TurkeyThe application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of biochromatography and related biomedical applications. These matrices nearly mimic the three-dimensional structure of native tissue extracellular matrix. In addition, mechanical, osmotic and chemical stability of cryogels make them attractive polymeric materials for the construction of scaffolds in tissue engineering applications and in vitro cell culture, separation materials for many different processes such as immobilization of biomolecules, capturing of target molecules, and controlled drug delivery. The low mass transfer resistance of cryogel matrices makes them useful in chromatographic applications with the immobilization of different affinity ligands to these materials. Cryogels have been introduced as gel matrices prepared using partially frozen monomer or polymer solutions at temperature below zero. These materials can be produced with different shapes and are of interest in the therapeutic area. This review highlights the recent advances in cryogelation technologies by emphasizing their biomedical applications to supply an overview of their rising stars day to day.https://www.mdpi.com/2076-3417/9/3/553supermacroporous cryogelpurificationseparationtissue engineeringbioreactorcell separationscaffold |
| spellingShingle | Monireh Bakhshpour Neslihan Idil Işık Perçin Adil Denizli Biomedical Applications of Polymeric Cryogels Applied Sciences supermacroporous cryogel purification separation tissue engineering bioreactor cell separation scaffold |
| title | Biomedical Applications of Polymeric Cryogels |
| title_full | Biomedical Applications of Polymeric Cryogels |
| title_fullStr | Biomedical Applications of Polymeric Cryogels |
| title_full_unstemmed | Biomedical Applications of Polymeric Cryogels |
| title_short | Biomedical Applications of Polymeric Cryogels |
| title_sort | biomedical applications of polymeric cryogels |
| topic | supermacroporous cryogel purification separation tissue engineering bioreactor cell separation scaffold |
| url | https://www.mdpi.com/2076-3417/9/3/553 |
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