Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease
Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/2045 |
| _version_ | 1797524321765163008 |
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| author | Zachary Finkel Fatima Esteban Brianna Rodriguez Tianyue Fu Xin Ai Li Cai |
| author_facet | Zachary Finkel Fatima Esteban Brianna Rodriguez Tianyue Fu Xin Ai Li Cai |
| author_sort | Zachary Finkel |
| collection | DOAJ |
| description | Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine. |
| first_indexed | 2024-03-10T08:55:42Z |
| format | Article |
| id | doaj.art-9c01191c200c4663980bf39091247546 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:55:42Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9c01191c200c4663980bf390912475462023-11-22T07:10:57ZengMDPI AGCells2073-44092021-08-01108204510.3390/cells10082045Diversity of Adult Neural Stem and Progenitor Cells in Physiology and DiseaseZachary Finkel0Fatima Esteban1Brianna Rodriguez2Tianyue Fu3Xin Ai4Li Cai5Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USADepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USAAdult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine.https://www.mdpi.com/2073-4409/10/8/2045central nervous system (CNS)ependymal cellsneural stem and progenitor cells (NSPC)NG2+ cellsneurodegenerative diseasesregenerative medicine |
| spellingShingle | Zachary Finkel Fatima Esteban Brianna Rodriguez Tianyue Fu Xin Ai Li Cai Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease Cells central nervous system (CNS) ependymal cells neural stem and progenitor cells (NSPC) NG2+ cells neurodegenerative diseases regenerative medicine |
| title | Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease |
| title_full | Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease |
| title_fullStr | Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease |
| title_full_unstemmed | Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease |
| title_short | Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease |
| title_sort | diversity of adult neural stem and progenitor cells in physiology and disease |
| topic | central nervous system (CNS) ependymal cells neural stem and progenitor cells (NSPC) NG2+ cells neurodegenerative diseases regenerative medicine |
| url | https://www.mdpi.com/2073-4409/10/8/2045 |
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