Helicobacter pylori-negative Gastric Cancer
Although Helicobacter pylori is considered the main etiological factor in gastric cancer, at least 5.4% of gastric cancer cases in South Korean patients are H. pylori-negative. However, false-negative H. pylori results should be considered. The definitions of H. pylori status in patients with atroph...
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| Format: | Article |
| Language: | English |
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Yong Chan Lee
2017-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.118 |
| _version_ | 1828298412561268736 |
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| author | Jin Seok Jang |
| author_facet | Jin Seok Jang |
| author_sort | Jin Seok Jang |
| collection | DOAJ |
| description | Although Helicobacter pylori is considered the main etiological factor in gastric cancer, at least 5.4% of gastric cancer cases in South Korean patients are H. pylori-negative. However, false-negative H. pylori results should be considered. The definitions of H. pylori status in patients with atrophic gastritis but negative tests for H. pylori are variable. Inaccurate H. pylori detection systems can interfere with interpretation of the results. Even when H. pylori has been eradicated, gastric atrophy and intestinal metaplasia resulting from long-term colonization can occur. It is very difficult to determine whether patients with gastric cancer, who frequently have advanced gastric atrophy and intestinal metaplasia, have had previous H. pylori infection based on invasive tests. In addition, H. pylori-negative gastric cancers present with a more advanced pT classification and a more advanced stage than H. pylori-positive gastric cancers. Negative H. pylori status appears to be an indicator of poor prognosis in patients with gastric cancer, and is independent of other well-known clinical and pathologic prognostic variables. |
| first_indexed | 2024-04-13T12:40:16Z |
| format | Article |
| id | doaj.art-9c04e51289c441f899e4ce1ebe1053c4 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-04-13T12:40:16Z |
| publishDate | 2017-09-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-9c04e51289c441f899e4ce1ebe1053c42022-12-22T02:46:32ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312017-09-0117311812110.7704/kjhugr.2017.17.3.118kjhugr.2017.17.3.118Helicobacter pylori-negative Gastric CancerJin Seok Jang0Department of Internal Medicine, Dong-A University College of Medicine, Busan, KoreaAlthough Helicobacter pylori is considered the main etiological factor in gastric cancer, at least 5.4% of gastric cancer cases in South Korean patients are H. pylori-negative. However, false-negative H. pylori results should be considered. The definitions of H. pylori status in patients with atrophic gastritis but negative tests for H. pylori are variable. Inaccurate H. pylori detection systems can interfere with interpretation of the results. Even when H. pylori has been eradicated, gastric atrophy and intestinal metaplasia resulting from long-term colonization can occur. It is very difficult to determine whether patients with gastric cancer, who frequently have advanced gastric atrophy and intestinal metaplasia, have had previous H. pylori infection based on invasive tests. In addition, H. pylori-negative gastric cancers present with a more advanced pT classification and a more advanced stage than H. pylori-positive gastric cancers. Negative H. pylori status appears to be an indicator of poor prognosis in patients with gastric cancer, and is independent of other well-known clinical and pathologic prognostic variables.http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.118Gastric cancerHelicobacter pyloriNegativityPrognosis |
| spellingShingle | Jin Seok Jang Helicobacter pylori-negative Gastric Cancer The Korean Journal of Helicobacter and Upper Gastrointestinal Research Gastric cancer Helicobacter pylori Negativity Prognosis |
| title | Helicobacter pylori-negative Gastric Cancer |
| title_full | Helicobacter pylori-negative Gastric Cancer |
| title_fullStr | Helicobacter pylori-negative Gastric Cancer |
| title_full_unstemmed | Helicobacter pylori-negative Gastric Cancer |
| title_short | Helicobacter pylori-negative Gastric Cancer |
| title_sort | helicobacter pylori negative gastric cancer |
| topic | Gastric cancer Helicobacter pylori Negativity Prognosis |
| url | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.118 |
| work_keys_str_mv | AT jinseokjang helicobacterpylorinegativegastriccancer |