SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

Abstract Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice and cultured pulmonary vascular endotheli...

Full description

Bibliographic Details
Main Authors: Kai Yang, Shiyun Liu, Han Yan, Wenju Lu, Xiaoqian Shan, Haixia Chen, Changlei Bao, Huazhuo Feng, Jing Liao, Shuxin Liang, Lei Xu, Haiyang Tang, Jason X.-J. Yuan, Nanshan Zhong, Jian Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01556-8

Similar Items

Similar Items