Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases
The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of n...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02164/full |
| _version_ | 1819238787217096704 |
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| author | Zhenyu Wu Zhenyu Wu Zhenyu Wu Lifu Wang Lifu Wang Lifu Wang Yanlai Tang Xi Sun Xi Sun Xi Sun |
| author_facet | Zhenyu Wu Zhenyu Wu Zhenyu Wu Lifu Wang Lifu Wang Lifu Wang Yanlai Tang Xi Sun Xi Sun Xi Sun |
| author_sort | Zhenyu Wu |
| collection | DOAJ |
| description | The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually. Epidemiological investigation has revealed that the increase also parallels a decrease in infectious diseases, especially parasitic infections. Thus, the reduced prevalence of parasitic infections may be another important reason for immune dysregulation. Parasites have co-evolved with the human immune system for a long time. Some parasite-derived immune-evasion molecules have been verified to reduce the incidence and harmfulness of atopic diseases in humans by modulating the immune response. More importantly, some parasite-derived products have been shown to inhibit the progression of inflammatory diseases and consequently alleviate their symptoms. Thus, parasites, and especially their products, may have potential applications in the treatment of autoimmune diseases. In this review, the potential of parasite-derived products and their analogs for use in the treatment of atopic diseases and immune dysregulation is summarized. |
| first_indexed | 2024-12-23T13:41:46Z |
| format | Article |
| id | doaj.art-9c088d84786f417ea46bed7e4c2ba3ae |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-23T13:41:46Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9c088d84786f417ea46bed7e4c2ba3ae2022-12-21T17:44:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-11-01810.3389/fmicb.2017.02164286803Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune DiseasesZhenyu Wu0Zhenyu Wu1Zhenyu Wu2Lifu Wang3Lifu Wang4Lifu Wang5Yanlai Tang6Xi Sun7Xi Sun8Xi Sun9Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, ChinaProvincial Engineering Technology Research Center for Diseases-Vectors Control, Guangzhou, ChinaDepartment of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, ChinaProvincial Engineering Technology Research Center for Diseases-Vectors Control, Guangzhou, ChinaDepartment of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, ChinaKey Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, ChinaProvincial Engineering Technology Research Center for Diseases-Vectors Control, Guangzhou, ChinaThe morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually. Epidemiological investigation has revealed that the increase also parallels a decrease in infectious diseases, especially parasitic infections. Thus, the reduced prevalence of parasitic infections may be another important reason for immune dysregulation. Parasites have co-evolved with the human immune system for a long time. Some parasite-derived immune-evasion molecules have been verified to reduce the incidence and harmfulness of atopic diseases in humans by modulating the immune response. More importantly, some parasite-derived products have been shown to inhibit the progression of inflammatory diseases and consequently alleviate their symptoms. Thus, parasites, and especially their products, may have potential applications in the treatment of autoimmune diseases. In this review, the potential of parasite-derived products and their analogs for use in the treatment of atopic diseases and immune dysregulation is summarized.http://journal.frontiersin.org/article/10.3389/fmicb.2017.02164/fullparasiteproducthygiene hypothesisautoimmune diseaseallergy |
| spellingShingle | Zhenyu Wu Zhenyu Wu Zhenyu Wu Lifu Wang Lifu Wang Lifu Wang Yanlai Tang Xi Sun Xi Sun Xi Sun Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases Frontiers in Microbiology parasite product hygiene hypothesis autoimmune disease allergy |
| title | Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases |
| title_full | Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases |
| title_fullStr | Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases |
| title_full_unstemmed | Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases |
| title_short | Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases |
| title_sort | parasite derived proteins for the treatment of allergies and autoimmune diseases |
| topic | parasite product hygiene hypothesis autoimmune disease allergy |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02164/full |
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