Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy
We present the case of a 22-year-old male with chronic hepatitis B virus (HBV) infection, who developed nephrotic syndrome and had complete remission after lamivudine monotherapy. Renal biopsy showed membranous glomerulopathy, and the serum titer of HBV DNA increased to 1,130,000 copies/mL. As sympt...
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| Format: | Article |
| Language: | English |
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Elsevier
2007-10-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664608600546 |
| _version_ | 1818539171977887744 |
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| author | Tang-Wei Chuang Chao-Hung Hung Shun-Chen Huang Chuan-Mo Lee |
| author_facet | Tang-Wei Chuang Chao-Hung Hung Shun-Chen Huang Chuan-Mo Lee |
| author_sort | Tang-Wei Chuang |
| collection | DOAJ |
| description | We present the case of a 22-year-old male with chronic hepatitis B virus (HBV) infection, who developed nephrotic syndrome and had complete remission after lamivudine monotherapy. Renal biopsy showed membranous glomerulopathy, and the serum titer of HBV DNA increased to 1,130,000 copies/mL. As symptomatic therapy with angiotensin converting enzyme inhibitors did not improve the nephrotic syndrome, lamivudine 100 mg per day was started. His alanine aminotransferase level normalized 2 months after treatment, then hepatitis B e antigen seroconversion developed and serum HBV DNA became undetectable. His proteinuria improved subsequently and his leg edema disappeared completely 6 months after treatment. Neither hepatitis nor nephrotic syndrome had relapsed by month 13 when he came for follow-up. This suggests that lamivudine monotherapy may induce and maintain complete remission of membranous glomerulopathy associated with hepatitis B. |
| first_indexed | 2024-12-11T21:38:32Z |
| format | Article |
| id | doaj.art-9c08cf12bab94190bc8b288ecec8c798 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T21:38:32Z |
| publishDate | 2007-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-9c08cf12bab94190bc8b288ecec8c7982022-12-22T00:49:55ZengElsevierJournal of the Formosan Medical Association0929-66462007-10-011061086987310.1016/S0929-6646(08)60054-6Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine MonotherapyTang-Wei Chuang0Chao-Hung Hung1Shun-Chen Huang2Chuan-Mo Lee3Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung, TaiwanDepartment of Pathology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung, TaiwanWe present the case of a 22-year-old male with chronic hepatitis B virus (HBV) infection, who developed nephrotic syndrome and had complete remission after lamivudine monotherapy. Renal biopsy showed membranous glomerulopathy, and the serum titer of HBV DNA increased to 1,130,000 copies/mL. As symptomatic therapy with angiotensin converting enzyme inhibitors did not improve the nephrotic syndrome, lamivudine 100 mg per day was started. His alanine aminotransferase level normalized 2 months after treatment, then hepatitis B e antigen seroconversion developed and serum HBV DNA became undetectable. His proteinuria improved subsequently and his leg edema disappeared completely 6 months after treatment. Neither hepatitis nor nephrotic syndrome had relapsed by month 13 when he came for follow-up. This suggests that lamivudine monotherapy may induce and maintain complete remission of membranous glomerulopathy associated with hepatitis B.http://www.sciencedirect.com/science/article/pii/S0929664608600546hepatitis B viruslamivudinemembranous glomerulonephritisnephrotic syndrome |
| spellingShingle | Tang-Wei Chuang Chao-Hung Hung Shun-Chen Huang Chuan-Mo Lee Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy Journal of the Formosan Medical Association hepatitis B virus lamivudine membranous glomerulonephritis nephrotic syndrome |
| title | Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy |
| title_full | Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy |
| title_fullStr | Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy |
| title_full_unstemmed | Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy |
| title_short | Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy |
| title_sort | complete remission of nephrotic syndrome of hepatitis b virus associated membranous glomerulopathy after lamivudine monotherapy |
| topic | hepatitis B virus lamivudine membranous glomerulonephritis nephrotic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S0929664608600546 |
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