Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin
<p>Abstract</p> <p>Background</p> <p>Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs) have attracted great interes...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/10/1/19 |
| _version_ | 1798041801692545024 |
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| author | Zhou Yan Kong Ying Kundu Subrata Cirillo Jeffrey D Liang Hong |
| author_facet | Zhou Yan Kong Ying Kundu Subrata Cirillo Jeffrey D Liang Hong |
| author_sort | Zhou Yan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs) have attracted great interest in drug development. The purpose of this study was to examine the potential of NPs as anti-TB compounds by studying the interacting mechanisms between NPs and bacteria.</p> <p>Results</p> <p>We investigated effects of gold and silver NPs on BCG and <it>Escherichia coli</it>. Experimentally, particle size and shape were characterized using transmission electron microscopy (TEM). Different concentrations of NPs were applied in bacterial culture. The growth of <it>E. coli</it> was monitored through colony forming units (CFU). The mechanism of interaction between NPs and bacteria was analyzed through bacterial thin sections followed by TEM and scanning electron microscopy. Antibacterial effects on BCG were observed by recording fluorescent protein expression levels.</p> <p>Conclusions</p> <p>The results suggest NPs have potential applications as anti-TB compounds. The antibacterial effects and mechanism of action for NPs were dependent upon composition and surface modifications.</p> |
| first_indexed | 2024-04-11T22:26:42Z |
| format | Article |
| id | doaj.art-9c0a66b7295d491497e6f390dacf9adf |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:26:42Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-9c0a66b7295d491497e6f390dacf9adf2022-12-22T03:59:38ZengBMCJournal of Nanobiotechnology1477-31552012-05-011011910.1186/1477-3155-10-19Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-GuérinZhou YanKong YingKundu SubrataCirillo Jeffrey DLiang Hong<p>Abstract</p> <p>Background</p> <p>Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs) have attracted great interest in drug development. The purpose of this study was to examine the potential of NPs as anti-TB compounds by studying the interacting mechanisms between NPs and bacteria.</p> <p>Results</p> <p>We investigated effects of gold and silver NPs on BCG and <it>Escherichia coli</it>. Experimentally, particle size and shape were characterized using transmission electron microscopy (TEM). Different concentrations of NPs were applied in bacterial culture. The growth of <it>E. coli</it> was monitored through colony forming units (CFU). The mechanism of interaction between NPs and bacteria was analyzed through bacterial thin sections followed by TEM and scanning electron microscopy. Antibacterial effects on BCG were observed by recording fluorescent protein expression levels.</p> <p>Conclusions</p> <p>The results suggest NPs have potential applications as anti-TB compounds. The antibacterial effects and mechanism of action for NPs were dependent upon composition and surface modifications.</p>http://www.biomedcentral.com/10/1/19Antibacterial effectGoldSilverNanoparticleBCG |
| spellingShingle | Zhou Yan Kong Ying Kundu Subrata Cirillo Jeffrey D Liang Hong Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin Journal of Nanobiotechnology Antibacterial effect Gold Silver Nanoparticle BCG |
| title | Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin |
| title_full | Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin |
| title_fullStr | Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin |
| title_full_unstemmed | Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin |
| title_short | Antibacterial activities of gold and silver nanoparticles against <it>Escherichia coli</it> and bacillus Calmette-Guérin |
| title_sort | antibacterial activities of gold and silver nanoparticles against it escherichia coli it and bacillus calmette guerin |
| topic | Antibacterial effect Gold Silver Nanoparticle BCG |
| url | http://www.biomedcentral.com/10/1/19 |
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