Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia
Objective: Previous studies compared the predictive ability of the European Treatment Outcome Study (EUTOS), Sokal, and Hasford scoring systems and demonstrated inconsistent findings with unknown reasons. This study was conducted to determine a useful scoring system to predict the prognosis of patie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-02-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-03443 |
| _version_ | 1797909119162646528 |
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| author | Jing Huang Leyan Wang Lu Chen He Qun Xu Yajing Chen Fangping Zhao Xielan |
| author_facet | Jing Huang Leyan Wang Lu Chen He Qun Xu Yajing Chen Fangping Zhao Xielan |
| author_sort | Jing Huang |
| collection | DOAJ |
| description | Objective: Previous studies compared the predictive ability of the European Treatment Outcome Study (EUTOS), Sokal, and Hasford scoring systems and demonstrated inconsistent findings with unknown reasons. This study was conducted to determine a useful scoring system to predict the prognosis of patients with chronic myeloid leukemia (CML) and identify the probable factors that affect the scoring. Materials and Methods: This is a retrospective cohort study. The predictive ability of EUTOS and the factors that affect scoring were analyzed in 234 Chinese chronic-phase CML patients treated with frontline imatinib, including a few patients temporarily administered hydroxyurea for cytoreduction before imatinib. Patients were stratified into different risk groups according to each scoring system to assess the treatment outcomes and the predictive ability of EUTOS scores between patients who received imatinib during the entire followup period and patients who received altered treatment because of intolerance, progression, and treatment failure. Results: Sixty-one (26.0%) patients received altered treatments during the follow-up. In the EUTOS low- and high-risk groups, the 5-year overall survival was 94.6% and 84.7% (p=0.011), 5-year eventfree survival was 92.6% and 77.6% (p=0.001), and 5-year progressionfree survival (PFS) was 95.3% and 82.4% (p=0.001), respectively. The predictive ability of EUTOS was better than that of the Sokal and Hasford scores (p=0.256, p=0.062, p=0.073) without statistical significance. All three scoring systems were valid in predicting early optimal response. Kaplan-Meier analysis showed a high association between overall PFS and the EUTOS scores in the standard-dose imatinib group (p<0.001). Conclusion: This study suggests that the EUTOS scoring system could predict the outcome of chronic-phase CML patients treated with standard-dose imatinib. Altered treatment is a crucial factor that affects the prognostic impact of EUTOS scoring. Achieving complete cytogenetic response at 18 months is an essential factor in predicting the prognosis of patients with CML. |
| first_indexed | 2024-04-10T11:04:43Z |
| format | Article |
| id | doaj.art-9c0da89229074bcca1306f59a93791de |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:04:43Z |
| publishDate | 2017-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-9c0da89229074bcca1306f59a93791de2023-02-15T16:19:31ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632017-02-01341101510.4274/tjh.2016.0156TJH-03443Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid LeukemiaJing Huang0Leyan Wang1Lu Chen2He Qun3Xu Yajing4Chen Fangping5Zhao Xielan6Xiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaXiangya Hospital, Central South University, Department of Hematology, Changsha, ChinaObjective: Previous studies compared the predictive ability of the European Treatment Outcome Study (EUTOS), Sokal, and Hasford scoring systems and demonstrated inconsistent findings with unknown reasons. This study was conducted to determine a useful scoring system to predict the prognosis of patients with chronic myeloid leukemia (CML) and identify the probable factors that affect the scoring. Materials and Methods: This is a retrospective cohort study. The predictive ability of EUTOS and the factors that affect scoring were analyzed in 234 Chinese chronic-phase CML patients treated with frontline imatinib, including a few patients temporarily administered hydroxyurea for cytoreduction before imatinib. Patients were stratified into different risk groups according to each scoring system to assess the treatment outcomes and the predictive ability of EUTOS scores between patients who received imatinib during the entire followup period and patients who received altered treatment because of intolerance, progression, and treatment failure. Results: Sixty-one (26.0%) patients received altered treatments during the follow-up. In the EUTOS low- and high-risk groups, the 5-year overall survival was 94.6% and 84.7% (p=0.011), 5-year eventfree survival was 92.6% and 77.6% (p=0.001), and 5-year progressionfree survival (PFS) was 95.3% and 82.4% (p=0.001), respectively. The predictive ability of EUTOS was better than that of the Sokal and Hasford scores (p=0.256, p=0.062, p=0.073) without statistical significance. All three scoring systems were valid in predicting early optimal response. Kaplan-Meier analysis showed a high association between overall PFS and the EUTOS scores in the standard-dose imatinib group (p<0.001). Conclusion: This study suggests that the EUTOS scoring system could predict the outcome of chronic-phase CML patients treated with standard-dose imatinib. Altered treatment is a crucial factor that affects the prognostic impact of EUTOS scoring. Achieving complete cytogenetic response at 18 months is an essential factor in predicting the prognosis of patients with CML.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-03443imatinibsokal scorehasford scoreeuropean treatment outcome study score |
| spellingShingle | Jing Huang Leyan Wang Lu Chen He Qun Xu Yajing Chen Fangping Zhao Xielan Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia Turkish Journal of Hematology imatinib sokal score hasford score european treatment outcome study score |
| title | Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia |
| title_full | Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia |
| title_fullStr | Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia |
| title_full_unstemmed | Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia |
| title_short | Changing Treatment May Affect the Predictive Ability of European Treatment Outcome Study Scoring for the Prognosis of Patients with Chronic Myeloid Leukemia |
| title_sort | changing treatment may affect the predictive ability of european treatment outcome study scoring for the prognosis of patients with chronic myeloid leukemia |
| topic | imatinib sokal score hasford score european treatment outcome study score |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-03443 |
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