Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder
Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD pat...
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MDPI AG
2022-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/12/1730 |
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| author | Shuai Zhang Jia-Kai He Gang-Liang Zhong Yu Wang Ya-Nan Zhao Lei Wang Shao-Yuan Li Xue Xiao Zheng-Yi Yang Bin Zhao Jin-Ling Zhang Tian-Zi Jiang Ji-Liang Fang Pei-Jing Rong |
| author_facet | Shuai Zhang Jia-Kai He Gang-Liang Zhong Yu Wang Ya-Nan Zhao Lei Wang Shao-Yuan Li Xue Xiao Zheng-Yi Yang Bin Zhao Jin-Ling Zhang Tian-Zi Jiang Ji-Liang Fang Pei-Jing Rong |
| author_sort | Shuai Zhang |
| collection | DOAJ |
| description | Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD patients were enrolled and treated with taVNS for 8 weeks. Sixteen healthy control subjects (HCs) were recruited without intervention. The resting-state FC (rsFC) based on striatal subregion seed points and the Hamilton Depression Scale (HAMD) were evaluated in the MDD patients and HCs at baseline and after 8 weeks. A two-way ANCOVA test was performed on each rsFC metric to obtain the (group-by-time) interactions. Results: The rsFC values between the left ventral caudate (vCa) and right ventral prefrontal cortex (vPFC), and between the right nucleus accumbens (NAc) and right dorsal medial prefrontal cortex (dmPFC) and ventrolateral prefrontal cortex (vlPFC) are lower in the MDD patients compared to the HCs at baseline, and increase following taVNS; the rsFC values between the left vCa and right, superior occipital gyrus (SOG), and between the left dorsal caudate (dCa) and right cuneus are higher in MDD patients and decrease following taVNS. Conclusions: Prolonged longitudinal taVNS can modulate the striatum rsFC with the prefrontal cortex, occipital cortex, temporal cortex, and intra-striatum, and these changes partly underlie any symptomatic improvements. The results indicate that prolonged longitudinal taVNS may produce beneficial treatment effects by modulating the cortical striatum circuitry in patients with MDD. |
| first_indexed | 2024-03-09T17:15:27Z |
| format | Article |
| id | doaj.art-9c0ea870d72142948655b38f49840b2d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T17:15:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9c0ea870d72142948655b38f49840b2d2023-11-24T13:40:42ZengMDPI AGBrain Sciences2076-34252022-12-011212173010.3390/brainsci12121730Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive DisorderShuai Zhang0Jia-Kai He1Gang-Liang Zhong2Yu Wang3Ya-Nan Zhao4Lei Wang5Shao-Yuan Li6Xue Xiao7Zheng-Yi Yang8Bin Zhao9Jin-Ling Zhang10Tian-Zi Jiang11Ji-Liang Fang12Pei-Jing Rong13Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaBrainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaDepartment of Psychiatry, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, ChinaBrainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Acupuncture, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaBrainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, ChinaDepartment of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaBackground: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective for treating major depressive disorder (MDD). We aimed to explore the modulating effect of prolonged longitudinal taVNS on the striatal subregions’ functional connectivity (FC) in MDD patients. Methods: Sixteen MDD patients were enrolled and treated with taVNS for 8 weeks. Sixteen healthy control subjects (HCs) were recruited without intervention. The resting-state FC (rsFC) based on striatal subregion seed points and the Hamilton Depression Scale (HAMD) were evaluated in the MDD patients and HCs at baseline and after 8 weeks. A two-way ANCOVA test was performed on each rsFC metric to obtain the (group-by-time) interactions. Results: The rsFC values between the left ventral caudate (vCa) and right ventral prefrontal cortex (vPFC), and between the right nucleus accumbens (NAc) and right dorsal medial prefrontal cortex (dmPFC) and ventrolateral prefrontal cortex (vlPFC) are lower in the MDD patients compared to the HCs at baseline, and increase following taVNS; the rsFC values between the left vCa and right, superior occipital gyrus (SOG), and between the left dorsal caudate (dCa) and right cuneus are higher in MDD patients and decrease following taVNS. Conclusions: Prolonged longitudinal taVNS can modulate the striatum rsFC with the prefrontal cortex, occipital cortex, temporal cortex, and intra-striatum, and these changes partly underlie any symptomatic improvements. The results indicate that prolonged longitudinal taVNS may produce beneficial treatment effects by modulating the cortical striatum circuitry in patients with MDD.https://www.mdpi.com/2076-3425/12/12/1730major depressive disorderprolonged longitudinal transcutaneous auricular vagus nerve stimulationstriatumcortical striatum circuitfunctional connectivity |
| spellingShingle | Shuai Zhang Jia-Kai He Gang-Liang Zhong Yu Wang Ya-Nan Zhao Lei Wang Shao-Yuan Li Xue Xiao Zheng-Yi Yang Bin Zhao Jin-Ling Zhang Tian-Zi Jiang Ji-Liang Fang Pei-Jing Rong Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder Brain Sciences major depressive disorder prolonged longitudinal transcutaneous auricular vagus nerve stimulation striatum cortical striatum circuit functional connectivity |
| title | Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder |
| title_full | Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder |
| title_fullStr | Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder |
| title_full_unstemmed | Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder |
| title_short | Prolonged Longitudinal Transcutaneous Auricular Vagus Nerve Stimulation Effect on Striatal Functional Connectivity in Patients with Major Depressive Disorder |
| title_sort | prolonged longitudinal transcutaneous auricular vagus nerve stimulation effect on striatal functional connectivity in patients with major depressive disorder |
| topic | major depressive disorder prolonged longitudinal transcutaneous auricular vagus nerve stimulation striatum cortical striatum circuit functional connectivity |
| url | https://www.mdpi.com/2076-3425/12/12/1730 |
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