Breakage-fusion-bridge cycles and large insertions contribute to the rapid evolution of accessory chromosomes in a fungal pathogen.
Chromosomal rearrangements are a major driver of eukaryotic genome evolution, affecting speciation, pathogenicity and cancer progression. Changes in chromosome structure are often initiated by mis-repair of double-strand breaks in the DNA. Mis-repair is particularly likely when telomeres are lost or...
Main Authors: | Daniel Croll, Marcello Zala, Bruce A McDonald |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-06-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3681731?pdf=render |
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