Endothelial Dysfunction In Preeclampsia
Preeclampsia is a complication of pregnancy characterized by hypertension, edema, and proteinuria. Based on these signs, it is suggested that endothelial dysfunction plays a role in the pathogenesis of preeclampsia. The aims of this study were to know whether endothelial dysfunction occur in preecla...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2010-10-01
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| Series: | Makara Journal of Health Research |
| Subjects: | |
| Online Access: | http://journal.ui.ac.id/index.php/health/article/view/406 |
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| author | Rahajuningsih Dharma Noroyono Wibowo Hessyani P.T. Raranta |
| author_facet | Rahajuningsih Dharma Noroyono Wibowo Hessyani P.T. Raranta |
| author_sort | Rahajuningsih Dharma |
| collection | DOAJ |
| description | Preeclampsia is a complication of pregnancy characterized by hypertension, edema, and proteinuria. Based on these signs, it is suggested that endothelial dysfunction plays a role in the pathogenesis of preeclampsia. The aims of this study were to know whether endothelial dysfunction occur in preeclampsia by measuring the level of sVCAM-1, von Willebrand factor, and fibrin monomer. The relationship between markers of endothelial dysfunction and blood pressure would also be sought. In this cross-sectional study, 30 women at the 24 - 42 weeks of pregnancy with preeklampsia, were enrolled and control group comprised of fullterm pregnant women. The level of sVCAM-1 was determined by ELISA method using reagents from R&D system, while vWF level was measured by enzyme linked fluorescent assay (ELFA) using reagent from VIDAS bioMerieux, and fibrin monomer was detected by ethanol gelation test. The mean of sVCAM-1 level in the preeklampsia group and in the control group were 576.4 ng/mL, and 375.7 ng/mL, respectively while the standard deviation were 58.3 ng/mL, and 43 ng/mL, respectively. The mean of vWF level in the preeklampsia group and in the control group were 305.3% and 162.4%, respectively while the standard deviation were 107.4% and 33%, respectively. Moderate correlation were found between sVCAM-1 as well as vWF level with both systolic and diastolic pressure. Fibrin monomer was found in 28 out of 30 subjects of preeclampsia group, but only 1 out of 31 subjects in the control group. The results of this study indicated that endothelial dysfunction occurred in preeclampsia. |
| first_indexed | 2024-03-12T08:05:08Z |
| format | Article |
| id | doaj.art-9c1212e9c5134e04957ef6b2e82282b0 |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-03-12T08:05:08Z |
| publishDate | 2010-10-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-9c1212e9c5134e04957ef6b2e82282b02023-09-02T19:39:13ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562010-10-0192636910.7454/msk.v9i2.406393Endothelial Dysfunction In PreeclampsiaRahajuningsih Dharma0Noroyono Wibowo1Hessyani P.T. Raranta2Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta 10230Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10230Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta 10230Preeclampsia is a complication of pregnancy characterized by hypertension, edema, and proteinuria. Based on these signs, it is suggested that endothelial dysfunction plays a role in the pathogenesis of preeclampsia. The aims of this study were to know whether endothelial dysfunction occur in preeclampsia by measuring the level of sVCAM-1, von Willebrand factor, and fibrin monomer. The relationship between markers of endothelial dysfunction and blood pressure would also be sought. In this cross-sectional study, 30 women at the 24 - 42 weeks of pregnancy with preeklampsia, were enrolled and control group comprised of fullterm pregnant women. The level of sVCAM-1 was determined by ELISA method using reagents from R&D system, while vWF level was measured by enzyme linked fluorescent assay (ELFA) using reagent from VIDAS bioMerieux, and fibrin monomer was detected by ethanol gelation test. The mean of sVCAM-1 level in the preeklampsia group and in the control group were 576.4 ng/mL, and 375.7 ng/mL, respectively while the standard deviation were 58.3 ng/mL, and 43 ng/mL, respectively. The mean of vWF level in the preeklampsia group and in the control group were 305.3% and 162.4%, respectively while the standard deviation were 107.4% and 33%, respectively. Moderate correlation were found between sVCAM-1 as well as vWF level with both systolic and diastolic pressure. Fibrin monomer was found in 28 out of 30 subjects of preeclampsia group, but only 1 out of 31 subjects in the control group. The results of this study indicated that endothelial dysfunction occurred in preeclampsia.http://journal.ui.ac.id/index.php/health/article/view/406endothelial dysfunctionpreeclampsialevel of sVCAM-1 |
| spellingShingle | Rahajuningsih Dharma Noroyono Wibowo Hessyani P.T. Raranta Endothelial Dysfunction In Preeclampsia Makara Journal of Health Research endothelial dysfunction preeclampsia level of sVCAM-1 |
| title | Endothelial Dysfunction In Preeclampsia |
| title_full | Endothelial Dysfunction In Preeclampsia |
| title_fullStr | Endothelial Dysfunction In Preeclampsia |
| title_full_unstemmed | Endothelial Dysfunction In Preeclampsia |
| title_short | Endothelial Dysfunction In Preeclampsia |
| title_sort | endothelial dysfunction in preeclampsia |
| topic | endothelial dysfunction preeclampsia level of sVCAM-1 |
| url | http://journal.ui.ac.id/index.php/health/article/view/406 |
| work_keys_str_mv | AT rahajuningsihdharma endothelialdysfunctioninpreeclampsia AT noroyonowibowo endothelialdysfunctioninpreeclampsia AT hessyaniptraranta endothelialdysfunctioninpreeclampsia |