Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate
The global spread of the metabolic syndrome, oncological and viral diseases forces researchers to pay increased attention to the secondary metabolites of marine hydrobionts, which often have a high therapeutic potential in the treatment of these pathologies and are effective components of functional...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/7/426 |
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| author | Emma P. Kozlovskaya Aleksandr M. Popov Olga N. Styshova Aleksey I. Vakhrushev Tatyana A. Rutckova Anna B. Podvolotskaya Ludmila A. Tekutyeva |
| author_facet | Emma P. Kozlovskaya Aleksandr M. Popov Olga N. Styshova Aleksey I. Vakhrushev Tatyana A. Rutckova Anna B. Podvolotskaya Ludmila A. Tekutyeva |
| author_sort | Emma P. Kozlovskaya |
| collection | DOAJ |
| description | The global spread of the metabolic syndrome, oncological and viral diseases forces researchers to pay increased attention to the secondary metabolites of marine hydrobionts, which often have a high therapeutic potential in the treatment of these pathologies and are effective components of functional food. The flavone luteolin (LT), as one of the most widely distributed and studied plant metabolites, is distinguished by a diverse spectrum of biological activity and a pleiotropic nature of the mechanism of action at the molecular, cellular and organismal levels. However, there is still practically no information on the spectrum of biological activity of its sulfated derivatives, which are widely represented in seagrasses of the genus Zostera. In the present work, a comparative study of the pharmacological properties of LT and its 7,3′-disulfate was carried out with a brief analysis of the special role of sulfation in the pharmacological activity of flavonoids. |
| first_indexed | 2024-03-09T13:29:25Z |
| format | Article |
| id | doaj.art-9c13d6bf21504617bee163621389ab00 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T13:29:25Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9c13d6bf21504617bee163621389ab002023-11-30T21:20:08ZengMDPI AGMarine Drugs1660-33972022-06-0120742610.3390/md20070426Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-DisulfateEmma P. Kozlovskaya0Aleksandr M. Popov1Olga N. Styshova2Aleksey I. Vakhrushev3Tatyana A. Rutckova4Anna B. Podvolotskaya5Ludmila A. Tekutyeva6G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 159 Prospect 100-Letiya Vladivostoka, Vladivostok 690022, RussiaDepartment of Bioeconomy and Food Security, School of Economics and Management, Far Eastern Federal University, Vladivostok 690922, RussiaDepartment of Bioeconomy and Food Security, School of Economics and Management, Far Eastern Federal University, Vladivostok 690922, RussiaThe global spread of the metabolic syndrome, oncological and viral diseases forces researchers to pay increased attention to the secondary metabolites of marine hydrobionts, which often have a high therapeutic potential in the treatment of these pathologies and are effective components of functional food. The flavone luteolin (LT), as one of the most widely distributed and studied plant metabolites, is distinguished by a diverse spectrum of biological activity and a pleiotropic nature of the mechanism of action at the molecular, cellular and organismal levels. However, there is still practically no information on the spectrum of biological activity of its sulfated derivatives, which are widely represented in seagrasses of the genus Zostera. In the present work, a comparative study of the pharmacological properties of LT and its 7,3′-disulfate was carried out with a brief analysis of the special role of sulfation in the pharmacological activity of flavonoids.https://www.mdpi.com/1660-3397/20/7/426luteolin (LT)luteolin 7,3′-disulfate (DSL)flavonoidssulfated flavonoidspharmacological activity |
| spellingShingle | Emma P. Kozlovskaya Aleksandr M. Popov Olga N. Styshova Aleksey I. Vakhrushev Tatyana A. Rutckova Anna B. Podvolotskaya Ludmila A. Tekutyeva Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate Marine Drugs luteolin (LT) luteolin 7,3′-disulfate (DSL) flavonoids sulfated flavonoids pharmacological activity |
| title | Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate |
| title_full | Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate |
| title_fullStr | Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate |
| title_full_unstemmed | Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate |
| title_short | Comparative Study of the Pharmacological Properties of Luteolin and Its 7,3′-Disulfate |
| title_sort | comparative study of the pharmacological properties of luteolin and its 7 3 disulfate |
| topic | luteolin (LT) luteolin 7,3′-disulfate (DSL) flavonoids sulfated flavonoids pharmacological activity |
| url | https://www.mdpi.com/1660-3397/20/7/426 |
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