The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma
Abstract Objective Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (ESCC) has not been fully clarified. Methods A total of 562 ESCC cases we...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11602-x |
| _version_ | 1797630181019484160 |
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| author | Xiaoqin Xu Weigang Wang Baoguo Tian Xiaofang Zhang Yanfen Ji Jiexian Jing |
| author_facet | Xiaoqin Xu Weigang Wang Baoguo Tian Xiaofang Zhang Yanfen Ji Jiexian Jing |
| author_sort | Xiaoqin Xu |
| collection | DOAJ |
| description | Abstract Objective Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (ESCC) has not been fully clarified. Methods A total of 562 ESCC cases were collected in our study, with available information on preoperative serum levels of TSGF at diagnosis. Preoperative serum TSGF was detected using the rate method. We retrospectively analyzed its correlation with clinicopathological features of ESCC and survival. Results The cut-off value of serum TSGF was determined to be 60.5 U/mL by receiver operating characteristic (ROC) analysis. Serum TSGF was associated with gender (P < 0.001), tumor location (P = 0.022), tobacco use (P < 0.001), alcohol consumption (P < 0.001), lymph node involvement (P = 0.007), and TNM staging (P = 0.004). The survival analysis revealed that ESCC patients with high levels of serum TSGF had poorer prognosis than those with high TSGF (P = 0.006), especially for male ESCC cases (P = 0.001), under 60 year (P = 0.036), male middle location (P = 0.023), tobacco consumption (P = 0.004), G1 + G2 (P = 0.031), advanced T staging (P = 0.033), lymph node involvement (P = 0.003), TNM staging (P = 0.003). Univariate Cox regression analysis indicated that exposure to smoking and drinking, tumor grade, T staging, lymph node metastasis, TNM staging, and serum TSGF level were the prognosis-related factors of ESCC. Multivariate regression analysis revealed that smoking history, higher serum TSGF levels, and advanced T stage enhanced the risk of ESCC-related death. Conclusion In brief, serum TSGF levels had in relation to malignant features of ESCC. It was positively correlated with survival but was identified as an independent risk factor for ESCC. |
| first_indexed | 2024-03-11T11:04:33Z |
| format | Article |
| id | doaj.art-9c13e73a25904246b56420ced4f8b326 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-11T11:04:33Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9c13e73a25904246b56420ced4f8b3262023-11-12T12:20:26ZengBMCBMC Cancer1471-24072023-11-012311810.1186/s12885-023-11602-xThe predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinomaXiaoqin Xu0Weigang Wang1Baoguo Tian2Xiaofang Zhang3Yanfen Ji4Jiexian Jing5Department of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityDepartment of Clinical Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityAbstract Objective Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (ESCC) has not been fully clarified. Methods A total of 562 ESCC cases were collected in our study, with available information on preoperative serum levels of TSGF at diagnosis. Preoperative serum TSGF was detected using the rate method. We retrospectively analyzed its correlation with clinicopathological features of ESCC and survival. Results The cut-off value of serum TSGF was determined to be 60.5 U/mL by receiver operating characteristic (ROC) analysis. Serum TSGF was associated with gender (P < 0.001), tumor location (P = 0.022), tobacco use (P < 0.001), alcohol consumption (P < 0.001), lymph node involvement (P = 0.007), and TNM staging (P = 0.004). The survival analysis revealed that ESCC patients with high levels of serum TSGF had poorer prognosis than those with high TSGF (P = 0.006), especially for male ESCC cases (P = 0.001), under 60 year (P = 0.036), male middle location (P = 0.023), tobacco consumption (P = 0.004), G1 + G2 (P = 0.031), advanced T staging (P = 0.033), lymph node involvement (P = 0.003), TNM staging (P = 0.003). Univariate Cox regression analysis indicated that exposure to smoking and drinking, tumor grade, T staging, lymph node metastasis, TNM staging, and serum TSGF level were the prognosis-related factors of ESCC. Multivariate regression analysis revealed that smoking history, higher serum TSGF levels, and advanced T stage enhanced the risk of ESCC-related death. Conclusion In brief, serum TSGF levels had in relation to malignant features of ESCC. It was positively correlated with survival but was identified as an independent risk factor for ESCC.https://doi.org/10.1186/s12885-023-11602-xEsophageal squamous cell carcinomaTumor-specific growth factorPrognosisMarker |
| spellingShingle | Xiaoqin Xu Weigang Wang Baoguo Tian Xiaofang Zhang Yanfen Ji Jiexian Jing The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma BMC Cancer Esophageal squamous cell carcinoma Tumor-specific growth factor Prognosis Marker |
| title | The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma |
| title_full | The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma |
| title_fullStr | The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma |
| title_full_unstemmed | The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma |
| title_short | The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma |
| title_sort | predicting role of serum tumor specific growth factor for prognosis of esophageal squamous cell carcinoma |
| topic | Esophageal squamous cell carcinoma Tumor-specific growth factor Prognosis Marker |
| url | https://doi.org/10.1186/s12885-023-11602-x |
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