Serum from a patient with GAD65 antibody-associated limbic encephalitis did not alter GABAergic neurotransmission in cultured hippocampal networks

Serum from a patient with GAD65 antibody-associated limbic encephalitis did not alter GABAergic neurotransmission in cultured hippocampal networks

Background: Glutamate decarboxylase (GAD) is an intracellular enzyme converting glutamate into GABA. Antibodies (ab) to its isoform GAD65 were described in limbic encephalitis (LE) and other neurological conditions. The significance of GAD65-ab for epilepsy is unclear, but alterations of inhibitory...

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Bibliographic Details
Main Authors: Nelly eStemmler, Karin eRohleder, Michael eMalter, Guido eWidman, Christian E Elger, Heinz eBeck, Rainer eSurges
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Neurology
Subjects:
Limbic Encephalitis
gabaergic neurotransmission
Hippocampal cultures
GAD65 antibodies
GABA(A) currents
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00189/full

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