Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

Abnormalities in astrocytes occur in the brains of patients with Tuberous Sclerosis Complex (TSC) and may contribute to the pathogenesis of neurological dysfunction in this disease. Here, we report that knock-out mice with Tsc1 gene inactivation in glia (Tsc1GFAPCKO mice) exhibit decreased expressio...

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Bibliographic Details
Main Authors: Lin Xu, Ling-Hui Zeng, Michael Wong
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Neurobiology of Disease
Subjects:
Tuberous sclerosis
Epilepsy
Seizures
Astrocyte
Glia
Connexin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000242

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