Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment
Introduction: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made pos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/14/3590 |
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| author | Valerio Nardone Luca Boldrini Roberta Grassi Davide Franceschini Ilaria Morelli Carlotta Becherini Mauro Loi Daniela Greto Isacco Desideri |
| author_facet | Valerio Nardone Luca Boldrini Roberta Grassi Davide Franceschini Ilaria Morelli Carlotta Becherini Mauro Loi Daniela Greto Isacco Desideri |
| author_sort | Valerio Nardone |
| collection | DOAJ |
| description | Introduction: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. Materials and Methods: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. Results: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. Conclusions: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials. |
| first_indexed | 2024-03-10T09:44:15Z |
| format | Article |
| id | doaj.art-9c189896897d4649bf6c00929fc36939 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:44:15Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9c189896897d4649bf6c00929fc369392023-11-22T03:25:52ZengMDPI AGCancers2072-66942021-07-011314359010.3390/cancers13143590Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored TreatmentValerio Nardone0Luca Boldrini1Roberta Grassi2Davide Franceschini3Ilaria Morelli4Carlotta Becherini5Mauro Loi6Daniela Greto7Isacco Desideri8Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyRadiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Milan, ItalyDepartment of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyDepartment of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, 50134 Florence, ItalyRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, ItalyRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, ItalyRadiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, ItalyIntroduction: Neoadjuvant radiotherapy is currently used mainly in locally advanced rectal cancer and sarcoma and in a subset of non-small cell lung cancer and esophageal cancer, whereas in other diseases it is under investigation. The evaluation of the efficacy of the induction strategy is made possible by performing imaging investigations before and after the neoadjuvant therapy and is usually challenging. In the last decade, texture analysis (TA) has been developed to help the radiologist to quantify and identify the parameters related to tumor heterogeneity, which cannot be appreciated by the naked eye. The aim of this narrative is to review the impact of TA on the prediction of response to neoadjuvant radiotherapy and or chemoradiotherapy. Materials and Methods: Key references were derived from a PubMed query. Hand searching and ClinicalTrials.gov were also used. Results: This paper contains a narrative report and a critical discussion of radiomics approaches in different fields of neoadjuvant radiotherapy, including esophageal cancer, lung cancer, sarcoma, and rectal cancer. Conclusions: Radiomics can shed a light on the setting of neoadjuvant therapies that can be used to tailor subsequent approaches or even to avoid surgery in the future. At the same, these results need to be validated in prospective and multicenter trials.https://www.mdpi.com/2072-6694/13/14/3590radiomicsneoadjuvant radiotherapytexture analysis |
| spellingShingle | Valerio Nardone Luca Boldrini Roberta Grassi Davide Franceschini Ilaria Morelli Carlotta Becherini Mauro Loi Daniela Greto Isacco Desideri Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment Cancers radiomics neoadjuvant radiotherapy texture analysis |
| title | Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment |
| title_full | Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment |
| title_fullStr | Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment |
| title_full_unstemmed | Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment |
| title_short | Radiomics in the Setting of Neoadjuvant Radiotherapy: A New Approach for Tailored Treatment |
| title_sort | radiomics in the setting of neoadjuvant radiotherapy a new approach for tailored treatment |
| topic | radiomics neoadjuvant radiotherapy texture analysis |
| url | https://www.mdpi.com/2072-6694/13/14/3590 |
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