Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. In this regard, uncoated bilosomes loaded with Ps (Ps/BLs) were nanoformulated...

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Bibliographic Details
Main Authors: Rana Ahmed Youness, Abdulaziz Mohsen Al-Mahallawi, Farah Haytham Mahmoud, Hind Atta, Maria Braoudaki, Sherif Ashraf Fahmy
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Polymers
Subjects:
psoralidin
chitosan
bilosomes
oral delivery
apoptosis
breast cancer
Online Access:https://www.mdpi.com/2073-4360/15/6/1464

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