Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice

Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice

Brown adipose tissue (BAT) is a major site of non-shivering thermogenesis in mammals and plays an important role in energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a master regulator of cellular metabolic homeostasis and numerous stress responses, has be...

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Bibliographic Details
Main Authors: Wei Shen, Suping Ren, Yongyong Hou, Zhuo Zuo, Shengnan Liu, Zhiyuan Liu, Jingqi Fu, Huihui Wang, Bei Yang, Rui Zhao, Yanyan Chen, Masayuki Yamamoto, Yuanyuan Xu, Qiang Zhang, Jingbo Pi
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
NFE2L1
brown adipocyte
BAT whitening
Lipolysis
snRNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172300280X

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