Delta-8 Tetrahydrocannabinol Product Impurities

Due to increased concerns regarding unidentified impurities in delta-8 tetrahydrocannabinol (Δ-8 THC) consumer products, a study using Nuclear Magnetic Resonance (NMR), high performance liquid chromatography (HPLC), and mass spectrometry (MS) was conducted to further investigate these products. Ten...

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Main Authors: Colleen L. Ray, Madison P. Bylo, Jonny Pescaglia, James A. Gawenis, C. Michael Greenlief
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/20/6924
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author Colleen L. Ray
Madison P. Bylo
Jonny Pescaglia
James A. Gawenis
C. Michael Greenlief
author_facet Colleen L. Ray
Madison P. Bylo
Jonny Pescaglia
James A. Gawenis
C. Michael Greenlief
author_sort Colleen L. Ray
collection DOAJ
description Due to increased concerns regarding unidentified impurities in delta-8 tetrahydrocannabinol (Δ-8 THC) consumer products, a study using Nuclear Magnetic Resonance (NMR), high performance liquid chromatography (HPLC), and mass spectrometry (MS) was conducted to further investigate these products. Ten Δ-8 THC products, including distillates and ready to use vaporizer cartridges, were analyzed. The results yield findings that the tested products contain several impurities in concentrations far beyond what is declared on certificates of analysis for these products. As Δ-8 THC is a synthetic product synthesized from cannabidiol (CBD), there are valid concerns regarding the presence of impurities in these products with unknown effects on the human body. Compounding this problem is apparent inadequate testing of these products by producers and independent laboratories.
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spelling doaj.art-9c1cdbce5d744f5c8b37dd71ded577612023-11-24T01:33:52ZengMDPI AGMolecules1420-30492022-10-012720692410.3390/molecules27206924Delta-8 Tetrahydrocannabinol Product ImpuritiesColleen L. Ray0Madison P. Bylo1Jonny Pescaglia2James A. Gawenis3C. Michael Greenlief4Department of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USADepartment of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USADepartment of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USASweetwater Science Laboratories, Glasgow, MO 65264, USADepartment of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USADue to increased concerns regarding unidentified impurities in delta-8 tetrahydrocannabinol (Δ-8 THC) consumer products, a study using Nuclear Magnetic Resonance (NMR), high performance liquid chromatography (HPLC), and mass spectrometry (MS) was conducted to further investigate these products. Ten Δ-8 THC products, including distillates and ready to use vaporizer cartridges, were analyzed. The results yield findings that the tested products contain several impurities in concentrations far beyond what is declared on certificates of analysis for these products. As Δ-8 THC is a synthetic product synthesized from cannabidiol (CBD), there are valid concerns regarding the presence of impurities in these products with unknown effects on the human body. Compounding this problem is apparent inadequate testing of these products by producers and independent laboratories.https://www.mdpi.com/1420-3049/27/20/6924NMRtetrahydrocannabinolcannabishempcannabidiolproduct safety
spellingShingle Colleen L. Ray
Madison P. Bylo
Jonny Pescaglia
James A. Gawenis
C. Michael Greenlief
Delta-8 Tetrahydrocannabinol Product Impurities
Molecules
NMR
tetrahydrocannabinol
cannabis
hemp
cannabidiol
product safety
title Delta-8 Tetrahydrocannabinol Product Impurities
title_full Delta-8 Tetrahydrocannabinol Product Impurities
title_fullStr Delta-8 Tetrahydrocannabinol Product Impurities
title_full_unstemmed Delta-8 Tetrahydrocannabinol Product Impurities
title_short Delta-8 Tetrahydrocannabinol Product Impurities
title_sort delta 8 tetrahydrocannabinol product impurities
topic NMR
tetrahydrocannabinol
cannabis
hemp
cannabidiol
product safety
url https://www.mdpi.com/1420-3049/27/20/6924
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