Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction
Hyperglycemia in pregnancy (HIP) is a high-glycemic state that occurs during pregnancy, and gestational diabetes mellitus (GDM) is the major cause of it. Studies reveal that GDM has long-term adverse impacts on mothers and offspring, such as maternal type 2 diabetes, premature birth and stillbirth i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Innovation Publishing House Pte. Ltd.
2021-06-01
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| Series: | STEMedicine |
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| Online Access: | https://stemedicine.org/index.php/stem/article/view/91 |
| _version_ | 1818879214039859200 |
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| author | Zemeng Xiao Yifang Wang Phung N. Thai Xuxia Li Xiyuan Lu Jun Pu |
| author_facet | Zemeng Xiao Yifang Wang Phung N. Thai Xuxia Li Xiyuan Lu Jun Pu |
| author_sort | Zemeng Xiao |
| collection | DOAJ |
| description | Hyperglycemia in pregnancy (HIP) is a high-glycemic state that occurs during pregnancy, and gestational diabetes mellitus (GDM) is the major cause of it. Studies reveal that GDM has long-term adverse impacts on mothers and offspring, such as maternal type 2 diabetes, premature birth and stillbirth in newborns, cardiovascular disease, and metabolic disorders in adult offspring. In recent years, studies on the transcription level of GDM and metabonomics have provided new insights into the pathophysiological mechanism of GDM. This article reviews the transcriptional levels and metabolomics studies involving GDM and cardiovascular dysfunction in the offspring, which may provide insight to the long-term health of pregnant women and offspring. |
| first_indexed | 2024-12-19T14:26:31Z |
| format | Article |
| id | doaj.art-9c1cffb1e0794b4e83bd4ab5a1aa6e82 |
| institution | Directory Open Access Journal |
| issn | 2705-1188 |
| language | English |
| last_indexed | 2024-12-19T14:26:31Z |
| publishDate | 2021-06-01 |
| publisher | Innovation Publishing House Pte. Ltd. |
| record_format | Article |
| series | STEMedicine |
| spelling | doaj.art-9c1cffb1e0794b4e83bd4ab5a1aa6e822022-12-21T20:17:36ZengInnovation Publishing House Pte. Ltd.STEMedicine2705-11882021-06-012710.37175/stemedicine.v2i7.91Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunctionZemeng Xiao0Yifang Wang1Phung N. Thai2Xuxia Li3Xiyuan Lu4Jun Pu5State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.Department of Internal Medicine, Cardiology, University of California, Davis.State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.State Key Laboratory for Oncogenes and Related Genes, Division of Cardiology, Renji Hospital, School of Medicine, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China.Hyperglycemia in pregnancy (HIP) is a high-glycemic state that occurs during pregnancy, and gestational diabetes mellitus (GDM) is the major cause of it. Studies reveal that GDM has long-term adverse impacts on mothers and offspring, such as maternal type 2 diabetes, premature birth and stillbirth in newborns, cardiovascular disease, and metabolic disorders in adult offspring. In recent years, studies on the transcription level of GDM and metabonomics have provided new insights into the pathophysiological mechanism of GDM. This article reviews the transcriptional levels and metabolomics studies involving GDM and cardiovascular dysfunction in the offspring, which may provide insight to the long-term health of pregnant women and offspring.https://stemedicine.org/index.php/stem/article/view/91PregnancyGDMTranscriptomicsMetabonomicsGlucoseInsulin resistance |
| spellingShingle | Zemeng Xiao Yifang Wang Phung N. Thai Xuxia Li Xiyuan Lu Jun Pu Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction STEMedicine Pregnancy GDM Transcriptomics Metabonomics Glucose Insulin resistance |
| title | Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| title_full | Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| title_fullStr | Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| title_full_unstemmed | Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| title_short | Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| title_sort | mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction |
| topic | Pregnancy GDM Transcriptomics Metabonomics Glucose Insulin resistance |
| url | https://stemedicine.org/index.php/stem/article/view/91 |
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