Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use
Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/17/5384 |
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| author | Srinivasa Rao Sirasanagandla Isehaq Al-Huseini Hussein Sakr Marzie Moqadass Srijit Das Norsham Juliana Izuddin Fahmy Abu |
| author_facet | Srinivasa Rao Sirasanagandla Isehaq Al-Huseini Hussein Sakr Marzie Moqadass Srijit Das Norsham Juliana Izuddin Fahmy Abu |
| author_sort | Srinivasa Rao Sirasanagandla |
| collection | DOAJ |
| description | Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has considerably increased over the past decades. Previous research studies have found a plethora of evidence of BPA’s harmful effects. Interestingly, even at a lower concentration, this industrial product was found to be harmful at cellular and tissue levels, affecting various body functions. A noble and possible treatment could be made plausible by using natural products (NPs). In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body’s reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems. The review also focuses on the targeted signaling pathways of NPs involved in BPA-induced toxicity. Although potential molecular mechanisms underlying BPA-induced toxicity have been investigated, there is currently no specific targeted treatment for BPA-induced toxicity. Hence, natural products could be considered for future therapeutic use against adverse and harmful effects of BPA exposure. |
| first_indexed | 2024-03-10T01:31:50Z |
| format | Article |
| id | doaj.art-9c1d914ec1494081946a0982519ca682 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:31:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9c1d914ec1494081946a0982519ca6822023-11-23T13:41:06ZengMDPI AGMolecules1420-30492022-08-012717538410.3390/molecules27175384Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic UseSrinivasa Rao Sirasanagandla0Isehaq Al-Huseini1Hussein Sakr2Marzie Moqadass3Srijit Das4Norsham Juliana5Izuddin Fahmy Abu6Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanCollege of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanDepartment of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, OmanFaculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Nilai 71800, MalaysiaInstitute of Medical Science Technology, Universiti Kuala Lumpur, Kuala Lumpur 50250, MalaysiaBisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has considerably increased over the past decades. Previous research studies have found a plethora of evidence of BPA’s harmful effects. Interestingly, even at a lower concentration, this industrial product was found to be harmful at cellular and tissue levels, affecting various body functions. A noble and possible treatment could be made plausible by using natural products (NPs). In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body’s reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems. The review also focuses on the targeted signaling pathways of NPs involved in BPA-induced toxicity. Although potential molecular mechanisms underlying BPA-induced toxicity have been investigated, there is currently no specific targeted treatment for BPA-induced toxicity. Hence, natural products could be considered for future therapeutic use against adverse and harmful effects of BPA exposure.https://www.mdpi.com/1420-3049/27/17/5384bisphenol Apollutanttoxicitytreatmentnatural productplastics |
| spellingShingle | Srinivasa Rao Sirasanagandla Isehaq Al-Huseini Hussein Sakr Marzie Moqadass Srijit Das Norsham Juliana Izuddin Fahmy Abu Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use Molecules bisphenol A pollutant toxicity treatment natural product plastics |
| title | Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use |
| title_full | Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use |
| title_fullStr | Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use |
| title_full_unstemmed | Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use |
| title_short | Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use |
| title_sort | natural products in mitigation of bisphenol a toxicity future therapeutic use |
| topic | bisphenol A pollutant toxicity treatment natural product plastics |
| url | https://www.mdpi.com/1420-3049/27/17/5384 |
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