Sphenopalatine Ganglion Stimulation Upregulates Transport of Temozolomide across the Blood-Brain Barrier

Sphenopalatine Ganglion Stimulation Upregulates Transport of Temozolomide across the Blood-Brain Barrier

Sphenopalatine ganglion (SPG) stimulation has been shown to reversibly alter blood-brain barrier (BBB) permeability. It is widely used for the treatment of cluster headaches in Europe and is well tolerated in humans. The therapeutic potential for SPG stimulation in other central nervous system (CNS)...

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Bibliographic Details
Main Authors: Thana N. Theofanis, Ankit K. Rochani, Richard F. Schmidt, Michael J. Lang, Geoffrey P. Stricsek, Robert H. Rosenwasser, Ashwini D. Sharan, Gagan Kaushal, Lorraine Iacovitti
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Scientia Pharmaceutica
Subjects:
sphenopalatine ganglion (SPG) stimulation
liquid chromatography mass spectrometry (LCMS)
temozolomide (TMZ)
blood brain barrier (BBB) penetration
Online Access:https://www.mdpi.com/2218-0532/88/3/40

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https://www.mdpi.com/2218-0532/88/3/40

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