Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4
Diabetes is a chronic hyperglycemic disorder that leads to a group of metabolic diseases. This condition of chronic hyperglycemia is caused by abnormal insulin levels. The impact of hyperglycemia on the human vascular tree is the leading cause of disease and death in type 1 and type 2 diabetes. Peop...
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/4/660 |
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| author | Afaf Aldahish Prasanalakshmi Balaji Rajalakshimi Vasudevan Geetha Kandasamy Jainey P. James Kousalya Prabahar |
| author_facet | Afaf Aldahish Prasanalakshmi Balaji Rajalakshimi Vasudevan Geetha Kandasamy Jainey P. James Kousalya Prabahar |
| author_sort | Afaf Aldahish |
| collection | DOAJ |
| description | Diabetes is a chronic hyperglycemic disorder that leads to a group of metabolic diseases. This condition of chronic hyperglycemia is caused by abnormal insulin levels. The impact of hyperglycemia on the human vascular tree is the leading cause of disease and death in type 1 and type 2 diabetes. People with type 2 diabetes mellitus (T2DM) have abnormal secretion as well as the action of insulin. Type 2 (non-insulin-dependent) diabetes is caused by a combination of genetic factors associated with decreased insulin production, insulin resistance, and environmental conditions. These conditions include overeating, lack of exercise, obesity, and aging. Glucose transport limits the rate of dietary glucose used by fat and muscle. The glucose transporter GLUT4 is kept intracellular and sorted dynamically, and GLUT4 translocation or insulin-regulated vesicular traffic distributes it to the plasma membrane. Different chemical compounds have antidiabetic properties. The complexity, metabolism, digestion, and interaction of these chemical compounds make it difficult to understand and apply them to reduce chronic inflammation and thus prevent chronic disease. In this study, we have applied a virtual screening approach to screen the most suitable and drug-able chemical compounds to be used as potential drug targets against T2DM. We have found that out of 5000 chemical compounds that we have analyzed, only two are known to be more effective as per our experiments based upon molecular docking studies and virtual screening through Lipinski’s rule and ADMET properties. |
| first_indexed | 2024-03-11T04:51:13Z |
| format | Article |
| id | doaj.art-9c207d4c996d4847922f6ee7f9d45cdc |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T04:51:13Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9c207d4c996d4847922f6ee7f9d45cdc2023-11-17T20:00:19ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113466010.3390/jpm13040660Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4Afaf Aldahish0Prasanalakshmi Balaji1Rajalakshimi Vasudevan2Geetha Kandasamy3Jainey P. James4Kousalya Prabahar5Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Computer Science, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Deralakatte, Mangaluru 575018, Karnataka, IndiaDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi ArabiaDiabetes is a chronic hyperglycemic disorder that leads to a group of metabolic diseases. This condition of chronic hyperglycemia is caused by abnormal insulin levels. The impact of hyperglycemia on the human vascular tree is the leading cause of disease and death in type 1 and type 2 diabetes. People with type 2 diabetes mellitus (T2DM) have abnormal secretion as well as the action of insulin. Type 2 (non-insulin-dependent) diabetes is caused by a combination of genetic factors associated with decreased insulin production, insulin resistance, and environmental conditions. These conditions include overeating, lack of exercise, obesity, and aging. Glucose transport limits the rate of dietary glucose used by fat and muscle. The glucose transporter GLUT4 is kept intracellular and sorted dynamically, and GLUT4 translocation or insulin-regulated vesicular traffic distributes it to the plasma membrane. Different chemical compounds have antidiabetic properties. The complexity, metabolism, digestion, and interaction of these chemical compounds make it difficult to understand and apply them to reduce chronic inflammation and thus prevent chronic disease. In this study, we have applied a virtual screening approach to screen the most suitable and drug-able chemical compounds to be used as potential drug targets against T2DM. We have found that out of 5000 chemical compounds that we have analyzed, only two are known to be more effective as per our experiments based upon molecular docking studies and virtual screening through Lipinski’s rule and ADMET properties.https://www.mdpi.com/2075-4426/13/4/660T2DMGLUT4ADMETCoFACTORChEMBLMOE |
| spellingShingle | Afaf Aldahish Prasanalakshmi Balaji Rajalakshimi Vasudevan Geetha Kandasamy Jainey P. James Kousalya Prabahar Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 Journal of Personalized Medicine T2DM GLUT4 ADMET CoFACTOR ChEMBL MOE |
| title | Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 |
| title_full | Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 |
| title_fullStr | Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 |
| title_full_unstemmed | Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 |
| title_short | Elucidating the Potential Inhibitor against Type 2 Diabetes Mellitus Associated Gene of GLUT4 |
| title_sort | elucidating the potential inhibitor against type 2 diabetes mellitus associated gene of glut4 |
| topic | T2DM GLUT4 ADMET CoFACTOR ChEMBL MOE |
| url | https://www.mdpi.com/2075-4426/13/4/660 |
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