Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast
Context and Aim: Breast carcinoma is one of the leading causes of cancer related mortality in females. A number of established prognostic indicators exist for breast cancer. One potential indicator of adverse prognosis in breast cancer is tumor induced angiogenesis. Hematogenous spread of tumor cell...
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2020-09-01
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| Series: | Asian Pacific Journal of Cancer Biology |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcb/article/view/425 |
| _version_ | 1797341124716658688 |
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| author | Bhawna Agnani Ranjana Solanki Maryem Ansari Sankalp Agnani |
| author_facet | Bhawna Agnani Ranjana Solanki Maryem Ansari Sankalp Agnani |
| author_sort | Bhawna Agnani |
| collection | DOAJ |
| description | Context and Aim: Breast carcinoma is one of the leading causes of cancer related mortality in females. A number of established prognostic indicators exist for breast cancer. One potential indicator of adverse prognosis in breast cancer is tumor induced angiogenesis. Hematogenous spread of tumor cells is quantitatively related to microvessel density (MVD). This study aims to find possible association of microvessel density with other recognized prognostic factor such as patient age, tumor size, lymph node status, histologic grade, Nottingham Prognostic Index (NPI), vascular invasion, hormone receptor status and HER2/Neu expression in breast carcinoma.
Methods and Materials: This is a cross sectional, laboratory based descriptive type of observational study. This study was carried out in the Department of Pathology, SMS medical college. In our study we did histological evaluation of mastectomy specimen of breast cancer including ER, PR and Her 2 status and calculated the microvessel density (MVD) in appropriate section by applying IHC. MVD correlation with other clinicopathological parameters was done. Stastical analysis used in this study include Fischer Exact test and Chi Square test.
Results: A significant correlation was obtained between MVD and tumor size, lymph node metastasis, lymphovascular invasion, histologic grade and NPI (P value of 0.01).
Conclusions: Angiogenesis is an important component of cancer growth, invasion and metastasis. Therefore, inhibition of angiogenesis is an attractive strategy for treatment of cancer. The correlation of MVD with prognosis suggests the utility of antiangiogenic drugs in breast cancer patients with high angiogenesis |
| first_indexed | 2024-03-08T10:13:49Z |
| format | Article |
| id | doaj.art-9c20fa3639c042c6b3982480b10fb35f |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:13:49Z |
| publishDate | 2020-09-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-9c20fa3639c042c6b3982480b10fb35f2024-01-29T06:13:10ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352020-09-0153757910.31557/apjcb.2020.5.3.75-79425Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of BreastBhawna Agnani0Ranjana Solanki1Maryem Ansari2Sankalp Agnani3Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.Department of Pathology, S.M.S. Medical College, Jaipur, Rajasthan, IndiaPandit Deen Dayal Hospital attached to SMS Hopital, Jaipur, Rajasthan, IndiaDepartment of Orthodontics,Pacific Dental College, Udaipur, Rajasthan , IndiaContext and Aim: Breast carcinoma is one of the leading causes of cancer related mortality in females. A number of established prognostic indicators exist for breast cancer. One potential indicator of adverse prognosis in breast cancer is tumor induced angiogenesis. Hematogenous spread of tumor cells is quantitatively related to microvessel density (MVD). This study aims to find possible association of microvessel density with other recognized prognostic factor such as patient age, tumor size, lymph node status, histologic grade, Nottingham Prognostic Index (NPI), vascular invasion, hormone receptor status and HER2/Neu expression in breast carcinoma. Methods and Materials: This is a cross sectional, laboratory based descriptive type of observational study. This study was carried out in the Department of Pathology, SMS medical college. In our study we did histological evaluation of mastectomy specimen of breast cancer including ER, PR and Her 2 status and calculated the microvessel density (MVD) in appropriate section by applying IHC. MVD correlation with other clinicopathological parameters was done. Stastical analysis used in this study include Fischer Exact test and Chi Square test. Results: A significant correlation was obtained between MVD and tumor size, lymph node metastasis, lymphovascular invasion, histologic grade and NPI (P value of 0.01). Conclusions: Angiogenesis is an important component of cancer growth, invasion and metastasis. Therefore, inhibition of angiogenesis is an attractive strategy for treatment of cancer. The correlation of MVD with prognosis suggests the utility of antiangiogenic drugs in breast cancer patients with high angiogenesishttp://www.waocp.com/journal/index.php/apjcb/article/view/425angiogenesis, breast cancer, microvessel density, prognostic significance. |
| spellingShingle | Bhawna Agnani Ranjana Solanki Maryem Ansari Sankalp Agnani Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast Asian Pacific Journal of Cancer Biology angiogenesis, breast cancer, microvessel density, prognostic significance. |
| title | Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast |
| title_full | Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast |
| title_fullStr | Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast |
| title_full_unstemmed | Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast |
| title_short | Prognostic Significance of Microvessel Density as Assessed by anti CD34 Monoclonal Antibody in Invasive Ductal Carcinoma of Breast |
| title_sort | prognostic significance of microvessel density as assessed by anti cd34 monoclonal antibody in invasive ductal carcinoma of breast |
| topic | angiogenesis, breast cancer, microvessel density, prognostic significance. |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/425 |
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