SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell degranulation, in an in vitro model for non-IgE-mediated hypersensitivity

SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell degranulation, in an in vitro model for non-IgE-mediated hypersensitivity

The development of vaccines against SARS-CoV2 brought about several challenges, including the management of hypersensitivity reactions to these formulations. The search for underlying mechanisms involved in these adverse events initially focused on excipients which may trigger mast cell activation r...

Full description

Bibliographic Details
Main Authors: Paola Leonor Quan, Laia Ollé, Marina Sabaté-Brescó, Yanru Guo, Rosa Muñoz-Cano, Annette Wagner, Gabriel Gastaminza, Margarita Martín
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Allergy
Subjects:
SARS-CoV-2 vaccines
polyethylene glycol
trometamol
mast cells
non-IgE-mediated hypersensitivity mast cell activation
MRGPRX2
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2022.1046545/full

Similar Items

Similar Items