Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

Abstract Background Obesity occurs when the body’s energy intake is constantly greater than its energy consumption and the pharmacological enhancing the activity of brown adipose tissue (BAT) and (or) browning of white adipose tissue (WAT) has been considered promising strategies to treat obesity. M...

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Bibliographic Details
Main Authors: Gang Wei, Honglin Sun, Jun-li Liu, Kai Dong, Junli Liu, Min Zhang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Nutrition & Metabolism
Subjects:
Connectivity MAP
Brown adipose tissue
Energy expenditure
Indirubin
Obesity
Online Access:http://link.springer.com/article/10.1186/s12986-020-00440-4

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