Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy
Spinocerebellar ataxia (SCA) 3 is a neurodegenerative disease which involves cerebellum and extra cerebellum. Neuropathy in SCA3 manifests in various ways, including axonal and demyelination lesions in sensory and motor nerves. There has not been any study that describes the peripheral neuropathy ch...
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2022-03-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2394 |
| _version_ | 1818207894243377152 |
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| author | Siti Aminah Sobana Iin Pusparini Nushrotul Lailiyya Ahmad Rizal Ganiem Uni Gamayani Yusuf Wibisono Fathul Huda Yunia Sribudiani Tri Hanggono Achmad |
| author_facet | Siti Aminah Sobana Iin Pusparini Nushrotul Lailiyya Ahmad Rizal Ganiem Uni Gamayani Yusuf Wibisono Fathul Huda Yunia Sribudiani Tri Hanggono Achmad |
| author_sort | Siti Aminah Sobana |
| collection | DOAJ |
| description | Spinocerebellar ataxia (SCA) 3 is a neurodegenerative disease which involves cerebellum and extra cerebellum. Neuropathy in SCA3 manifests in various ways, including axonal and demyelination lesions in sensory and motor nerves. There has not been any study that describes the peripheral neuropathy characteristics of SCA3 patients in Indonesia at the time of this publication. This paper reports a case of a 43-year-old male with known spinocerebellar ataxia 3 presented with hereditary ataxia and mild numbness in both palms since two years before. No abnormalities were found during the sensory examination. The NCS showed severe axonal demyelinating sensorimotor peripheral neuropathy. In magnetic resonance imaging (MRI), an atrophy in the cerebellum with cerebral multiple lacunar infarction was identified. Electrophysiological results revealed profound axonal lesion in peripheral nerves. To conclude, peripheral neuropathy in SCA3 represents the dominance of axonal lesions in motor nerves. |
| first_indexed | 2024-12-12T04:36:10Z |
| format | Article |
| id | doaj.art-9c25b22f9df34d058c53978e1df454c4 |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-12T04:36:10Z |
| publishDate | 2022-03-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-9c25b22f9df34d058c53978e1df454c42022-12-22T00:37:58ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232022-03-01541576210.15395/mkb.v54n1.23941412Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral NeuropathySiti Aminah Sobana0Iin Pusparini1Nushrotul Lailiyya2Ahmad Rizal Ganiem3Uni Gamayani4Yusuf Wibisono5Fathul Huda6Yunia Sribudiani7Tri Hanggono Achmad8Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDivision of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, BandungDivision of Biochemistry and Molecular Biology, Department of Biomedical Sciences, Faculty of Medicine Universitas Padjadjaran, BandungSpinocerebellar ataxia (SCA) 3 is a neurodegenerative disease which involves cerebellum and extra cerebellum. Neuropathy in SCA3 manifests in various ways, including axonal and demyelination lesions in sensory and motor nerves. There has not been any study that describes the peripheral neuropathy characteristics of SCA3 patients in Indonesia at the time of this publication. This paper reports a case of a 43-year-old male with known spinocerebellar ataxia 3 presented with hereditary ataxia and mild numbness in both palms since two years before. No abnormalities were found during the sensory examination. The NCS showed severe axonal demyelinating sensorimotor peripheral neuropathy. In magnetic resonance imaging (MRI), an atrophy in the cerebellum with cerebral multiple lacunar infarction was identified. Electrophysiological results revealed profound axonal lesion in peripheral nerves. To conclude, peripheral neuropathy in SCA3 represents the dominance of axonal lesions in motor nerves.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2394ncs, peripheral neuropathy, sca3 |
| spellingShingle | Siti Aminah Sobana Iin Pusparini Nushrotul Lailiyya Ahmad Rizal Ganiem Uni Gamayani Yusuf Wibisono Fathul Huda Yunia Sribudiani Tri Hanggono Achmad Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy Majalah Kedokteran Bandung ncs, peripheral neuropathy, sca3 |
| title | Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy |
| title_full | Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy |
| title_fullStr | Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy |
| title_full_unstemmed | Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy |
| title_short | Spinocerebellar Ataxia 3 (SCA3) Patient with Peripheral Neuropathy |
| title_sort | spinocerebellar ataxia 3 sca3 patient with peripheral neuropathy |
| topic | ncs, peripheral neuropathy, sca3 |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/2394 |
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