Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis
Ghrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities, cognition, memory, circadian rhythm and reward...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1324134/full |
| _version_ | 1797362407535804416 |
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| author | Jiang Zhu Jiang Zhu Tanfang Zhou Tanfang Zhou Meng Menggen Kalibixiati Aimulajiang Hao Wen Hao Wen |
| author_facet | Jiang Zhu Jiang Zhu Tanfang Zhou Tanfang Zhou Meng Menggen Kalibixiati Aimulajiang Hao Wen Hao Wen |
| author_sort | Jiang Zhu |
| collection | DOAJ |
| description | Ghrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities, cognition, memory, circadian rhythm and reward effects. In many benign liver diseases, it may play a hepatoprotective role against steatosis, chronic inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress and apoptosis, and improve liver cell autophagy and immune response to improve disease progression. However, the role of Ghrelin in liver Echinococcosis is currently unclear. This review systematically summarizes the molecular mechanisms by which Ghrelin regulates liver growth metabolism, immune-inflammation, fibrogenesis, proliferation and apoptosis, as well as its protective effects in liver fibrosis diseases, and further proposes the role of Ghrelin in liver Echinococcosis infection. During the infectious process, it may promote the parasitism and survival of parasites on the host by improving the immune-inflammatory microenvironment and fibrosis state, thereby accelerating disease progression. However, there is currently a lack of targeted in vitro and in vivo experimental evidence for this viewpoint. |
| first_indexed | 2024-03-08T16:06:37Z |
| format | Article |
| id | doaj.art-9c25fc878f3d40b6a93dba50c20b6f75 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T16:06:37Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9c25fc878f3d40b6a93dba50c20b6f752024-01-08T05:14:23ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011310.3389/fcimb.2023.13241341324134Ghrelin regulating liver activity and its potential effects on liver fibrosis and EchinococcosisJiang Zhu0Jiang Zhu1Tanfang Zhou2Tanfang Zhou3Meng Menggen4Kalibixiati Aimulajiang5Hao Wen6Hao Wen7State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Hepatobiliary and Hydatid Disease, Digestive and Vascular Surgery Center Therapy Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Hepatobiliary and Hydatid Disease, Digestive and Vascular Surgery Center Therapy Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaDepartment of Hepatobiliary and Hydatid Disease, Digestive and Vascular Surgery Center Therapy Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaGhrelin widely exists in the central nervous system and peripheral organs, and has biological activities such as maintaining energy homeostasis, regulating lipid metabolism, cell proliferation, immune response, gastrointestinal physiological activities, cognition, memory, circadian rhythm and reward effects. In many benign liver diseases, it may play a hepatoprotective role against steatosis, chronic inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress and apoptosis, and improve liver cell autophagy and immune response to improve disease progression. However, the role of Ghrelin in liver Echinococcosis is currently unclear. This review systematically summarizes the molecular mechanisms by which Ghrelin regulates liver growth metabolism, immune-inflammation, fibrogenesis, proliferation and apoptosis, as well as its protective effects in liver fibrosis diseases, and further proposes the role of Ghrelin in liver Echinococcosis infection. During the infectious process, it may promote the parasitism and survival of parasites on the host by improving the immune-inflammatory microenvironment and fibrosis state, thereby accelerating disease progression. However, there is currently a lack of targeted in vitro and in vivo experimental evidence for this viewpoint.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1324134/fullGhrelinliverfibrosisEchinococcosisIGF - I |
| spellingShingle | Jiang Zhu Jiang Zhu Tanfang Zhou Tanfang Zhou Meng Menggen Kalibixiati Aimulajiang Hao Wen Hao Wen Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis Frontiers in Cellular and Infection Microbiology Ghrelin liver fibrosis Echinococcosis IGF - I |
| title | Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis |
| title_full | Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis |
| title_fullStr | Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis |
| title_full_unstemmed | Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis |
| title_short | Ghrelin regulating liver activity and its potential effects on liver fibrosis and Echinococcosis |
| title_sort | ghrelin regulating liver activity and its potential effects on liver fibrosis and echinococcosis |
| topic | Ghrelin liver fibrosis Echinococcosis IGF - I |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1324134/full |
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