Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis
Background: TP73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding RNA (lncRNA), has been reported to be upregulated in various kinds of tumors, and shows a variable influence on living quality and prognosis of patients. Thus, we conducted a meta-analysis to evaluate the overall prognos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Electronic Journal of Biotechnology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0717345819300545 |
| _version_ | 1819126756976623616 |
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| author | Xiaoqing Wang Kunpeng Shu Zhifeng Wang Degang Ding Xing Li |
| author_facet | Xiaoqing Wang Kunpeng Shu Zhifeng Wang Degang Ding Xing Li |
| author_sort | Xiaoqing Wang |
| collection | DOAJ |
| description | Background: TP73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding RNA (lncRNA), has been reported to be upregulated in various kinds of tumors, and shows a variable influence on living quality and prognosis of patients. Thus, we conducted a meta-analysis to evaluate the overall prognostic value of the lncRNA TP73-AS1 in cancer patients. Results: A systematic literature retrieval was carried out using the PubMed, Cochrane Library, EMBASE, and Web of Science databases. We calculated the pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CIs) to evaluate the association of TP73-AS1 expression with prognostic and clinicopathological parameters. A total of 15 studies including 1057 cancer patients were finally selected for the meta-analysis. The results demonstrated that high TP73-AS1 expression was significantly associated with shorter overall survival (OS) (HR = 1.97, 95% CI: 1.68–2.31, P < 0.001). According to a fixed-effects or random-effects model, elevated TP73-AS1 expression markedly predicted advanced clinical stage (OR = 3.30, 95% CI: 2.35–4.64, P < 0.001), larger tumor size (OR = 2.37, 95% CI: 1.75–3.22, P < 0.001), earlier lymph node metastasis (OR = 3.28, 95% CI: 1.59–6.76, P = 0.001), and distant metastasis (OR = 4.94, 95% CI: 2.61–9.37, P < 0.001). Conclusions: High lncRNA TP73-AS1 expression appears to be predictive of a worse OS and clinicopathologic features for patients with various types of malignant tumors. These results provide a basis for utilizing TP73-AS1 expression as an unfavorable indicator to predict survival outcomes.How to cite: Wang X, Shu K, Wang Z, et al. Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis. Electron J Biotechnol 2020;43. https://doi.org/10.1016/j.ejbt.2019.12.005. Keywords: Carcinoma, Human cancer, lncRNA, Long noncoding RNA, Meta-analysis, Prognosis, TP73 antisense RNA, Tumors |
| first_indexed | 2024-12-22T08:01:06Z |
| format | Article |
| id | doaj.art-9c2645dd3062467a9779b8bf2af79f50 |
| institution | Directory Open Access Journal |
| issn | 0717-3458 |
| language | English |
| last_indexed | 2024-12-22T08:01:06Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Electronic Journal of Biotechnology |
| spelling | doaj.art-9c2645dd3062467a9779b8bf2af79f502022-12-21T18:33:14ZengElsevierElectronic Journal of Biotechnology0717-34582020-01-01433240Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysisXiaoqing Wang0Kunpeng Shu1Zhifeng Wang2Degang Ding3Xing Li4Department of Urology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, ChinaDepartment of Urology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China; Department of Urology, People's Hospital of Henan University, Zhengzhou 450003, ChinaDepartment of Urology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China; Department of Urology, People's Hospital of Henan University, Zhengzhou 450003, ChinaDepartment of Urology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China; Department of Urology, People's Hospital of Henan University, Zhengzhou 450003, China; Corresponding authors.Department of Urology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China; Corresponding authors.Background: TP73 antisense RNA 1 (TP73-AS1), a newly discovered long non-coding RNA (lncRNA), has been reported to be upregulated in various kinds of tumors, and shows a variable influence on living quality and prognosis of patients. Thus, we conducted a meta-analysis to evaluate the overall prognostic value of the lncRNA TP73-AS1 in cancer patients. Results: A systematic literature retrieval was carried out using the PubMed, Cochrane Library, EMBASE, and Web of Science databases. We calculated the pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CIs) to evaluate the association of TP73-AS1 expression with prognostic and clinicopathological parameters. A total of 15 studies including 1057 cancer patients were finally selected for the meta-analysis. The results demonstrated that high TP73-AS1 expression was significantly associated with shorter overall survival (OS) (HR = 1.97, 95% CI: 1.68–2.31, P < 0.001). According to a fixed-effects or random-effects model, elevated TP73-AS1 expression markedly predicted advanced clinical stage (OR = 3.30, 95% CI: 2.35–4.64, P < 0.001), larger tumor size (OR = 2.37, 95% CI: 1.75–3.22, P < 0.001), earlier lymph node metastasis (OR = 3.28, 95% CI: 1.59–6.76, P = 0.001), and distant metastasis (OR = 4.94, 95% CI: 2.61–9.37, P < 0.001). Conclusions: High lncRNA TP73-AS1 expression appears to be predictive of a worse OS and clinicopathologic features for patients with various types of malignant tumors. These results provide a basis for utilizing TP73-AS1 expression as an unfavorable indicator to predict survival outcomes.How to cite: Wang X, Shu K, Wang Z, et al. Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis. Electron J Biotechnol 2020;43. https://doi.org/10.1016/j.ejbt.2019.12.005. Keywords: Carcinoma, Human cancer, lncRNA, Long noncoding RNA, Meta-analysis, Prognosis, TP73 antisense RNA, Tumorshttp://www.sciencedirect.com/science/article/pii/S0717345819300545 |
| spellingShingle | Xiaoqing Wang Kunpeng Shu Zhifeng Wang Degang Ding Xing Li Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis Electronic Journal of Biotechnology |
| title | Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis |
| title_full | Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis |
| title_fullStr | Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis |
| title_short | Prognostic value of long non-coding RNA TP73-AS1 expression in different types of cancer: A systematic review and meta-analysis |
| title_sort | prognostic value of long non coding rna tp73 as1 expression in different types of cancer a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0717345819300545 |
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