<it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009
<p>Abstract</p> <p>Background</p> <p>Salmonellosis is one of the most important foodborne diseases and a major threat to public health. <it>Salmonella </it>serotype Virchow ranks among the top five serovars in Europe.</p> <p>Method</p> <...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-02-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/11/49 |
| _version_ | 1818564524000673792 |
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| author | Adank Luzius Cernela Nicole Käppeli Ursula Stephan Roger Bonalli Mario Hächler Herbert |
| author_facet | Adank Luzius Cernela Nicole Käppeli Ursula Stephan Roger Bonalli Mario Hächler Herbert |
| author_sort | Adank Luzius |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Salmonellosis is one of the most important foodborne diseases and a major threat to public health. <it>Salmonella </it>serotype Virchow ranks among the top five serovars in Europe.</p> <p>Method</p> <p>A total of 153 strains isolated from different patients from 2004 through 2009 in Switzerland were further characterized by (i) assessing phenotypic antibiotic resistance profiles using the disk diffusion method and (ii) by genotyping using pulsed-field gel electrophoresis (PFGE) after macrorestriction with <it>Xba</it>I in order to evaluate strain relationship.</p> <p>Results</p> <p>The relative frequency of <it>S</it>. Virchow among other <it>Salmonella </it>serovars varied between 4<sup>th </sup>to 8<sup>th </sup>rank. The annual incidence ranged from 0.45/100'000 in 2004 to 0.40/100'000 in 2009. A total of 48 strains (32%) were resistant to one to 3 antimicrobials, 54 strains (36%) displayed resistance patterns to more than three antibiotics. No trend was identifiable over the years 2004 to 2009. We found a high prevalence (62%) of nalidixic acid resistant strains, suggesting an equally high rate of decreased fluoroqionolone susceptibility, whereas intermediate resistance to ciprofloxacin was negligible. Two strains were extended spectrum β-lactamase (ESBL) producers. Analysis of PFGE patterns uncovered a predominant cluster (similarity coefficient above 80%) consisting of 104 of the 153 strains.</p> <p>Conclusion</p> <p>The worldwide increase of antibiotic resistances in <it>Salmonella </it>is an emerging public health problem. For Switzerland, no clear trend is identifiable over the years 2004 to 2009 for <it>S</it>. Virchow. Antimicrobial susceptibility and resistance profiles varied considerably within this period. Nevertheless, the situation in Switzerland coincided with findings in other European countries. Genotyping results of this strain collection revealed no evidence for an undetected outbreak within this time period.</p> |
| first_indexed | 2024-12-14T01:30:02Z |
| format | Article |
| id | doaj.art-9c26805ad6774a09977fb3d62d69a7a8 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T01:30:02Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-9c26805ad6774a09977fb3d62d69a7a82022-12-21T23:22:04ZengBMCBMC Infectious Diseases1471-23342011-02-011114910.1186/1471-2334-11-49<it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009Adank LuziusCernela NicoleKäppeli UrsulaStephan RogerBonalli MarioHächler Herbert<p>Abstract</p> <p>Background</p> <p>Salmonellosis is one of the most important foodborne diseases and a major threat to public health. <it>Salmonella </it>serotype Virchow ranks among the top five serovars in Europe.</p> <p>Method</p> <p>A total of 153 strains isolated from different patients from 2004 through 2009 in Switzerland were further characterized by (i) assessing phenotypic antibiotic resistance profiles using the disk diffusion method and (ii) by genotyping using pulsed-field gel electrophoresis (PFGE) after macrorestriction with <it>Xba</it>I in order to evaluate strain relationship.</p> <p>Results</p> <p>The relative frequency of <it>S</it>. Virchow among other <it>Salmonella </it>serovars varied between 4<sup>th </sup>to 8<sup>th </sup>rank. The annual incidence ranged from 0.45/100'000 in 2004 to 0.40/100'000 in 2009. A total of 48 strains (32%) were resistant to one to 3 antimicrobials, 54 strains (36%) displayed resistance patterns to more than three antibiotics. No trend was identifiable over the years 2004 to 2009. We found a high prevalence (62%) of nalidixic acid resistant strains, suggesting an equally high rate of decreased fluoroqionolone susceptibility, whereas intermediate resistance to ciprofloxacin was negligible. Two strains were extended spectrum β-lactamase (ESBL) producers. Analysis of PFGE patterns uncovered a predominant cluster (similarity coefficient above 80%) consisting of 104 of the 153 strains.</p> <p>Conclusion</p> <p>The worldwide increase of antibiotic resistances in <it>Salmonella </it>is an emerging public health problem. For Switzerland, no clear trend is identifiable over the years 2004 to 2009 for <it>S</it>. Virchow. Antimicrobial susceptibility and resistance profiles varied considerably within this period. Nevertheless, the situation in Switzerland coincided with findings in other European countries. Genotyping results of this strain collection revealed no evidence for an undetected outbreak within this time period.</p>http://www.biomedcentral.com/1471-2334/11/49 |
| spellingShingle | Adank Luzius Cernela Nicole Käppeli Ursula Stephan Roger Bonalli Mario Hächler Herbert <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 BMC Infectious Diseases |
| title | <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 |
| title_full | <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 |
| title_fullStr | <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 |
| title_full_unstemmed | <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 |
| title_short | <it>Salmonella enterica </it>serotype Virchow associated with human infections in Switzerland: 2004-2009 |
| title_sort | it salmonella enterica it serotype virchow associated with human infections in switzerland 2004 2009 |
| url | http://www.biomedcentral.com/1471-2334/11/49 |
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