Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of complex natural products, enabling the direct...

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Bibliographic Details
Main Authors:	Zaozao Xiao, Yuang Gu, Hewei Dong, Bo Liu, Weiwei Jin, Jie Li, Peixiang Ma, Hongtao Xu, Wei Hou
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	European Journal of Medicinal Chemistry Reports
Subjects:	CuAAC click chemistry Structural modification Molecular hybridization Natural products Anticancer activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417423000134

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