The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors
Antiretroviral Therapy (ART) is an effective treatment for human immunodeficiency virus (HIV) which has transformed the highly lethal disease, acquired immunodeficiency syndrome (AIDS), into a chronic and manageable condition. However, better methods need to be developed for enhancing patient access...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/11/2234 |
| _version_ | 1797457562565607424 |
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| author | Lívia da Rocha Fernandes Juliana Romano Lopes Andressa Francielli Bonjorno João Lucas Bruno Prates Cauê Benito Scarim Jean Leandro Dos Santos |
| author_facet | Lívia da Rocha Fernandes Juliana Romano Lopes Andressa Francielli Bonjorno João Lucas Bruno Prates Cauê Benito Scarim Jean Leandro Dos Santos |
| author_sort | Lívia da Rocha Fernandes |
| collection | DOAJ |
| description | Antiretroviral Therapy (ART) is an effective treatment for human immunodeficiency virus (HIV) which has transformed the highly lethal disease, acquired immunodeficiency syndrome (AIDS), into a chronic and manageable condition. However, better methods need to be developed for enhancing patient access and adherence to therapy and for improving treatment in the long term to reduce adverse effects. From the perspective of drug discovery, one promising strategy is the development of anti-HIV prodrugs. This approach aims to enhance the efficacy and safety of treatment, promoting the development of more appropriate and convenient systems for patients. In this review, we discussed the use of the prodrug approach for HIV antiviral agents and emphasized nucleoside reverse transcriptase inhibitors. We comprehensively described various strategies that are used to enhance factors such as water solubility, bioavailability, pharmacokinetic parameters, permeability across biological membranes, chemical stability, drug delivery to specific sites/organs, and tolerability. These strategies might help researchers conduct better studies in this field. We also reported successful examples from the primary therapeutic classes while discussing the advantages and limitations. In this review, we highlighted the key trends in the application of the prodrug approach for treating HIV/AIDS. |
| first_indexed | 2024-03-09T16:22:52Z |
| format | Article |
| id | doaj.art-9c270be1402446c7849bbfb55415bef4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T16:22:52Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9c270be1402446c7849bbfb55415bef42023-11-24T15:10:55ZengMDPI AGViruses1999-49152023-11-011511223410.3390/v15112234The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase InhibitorsLívia da Rocha Fernandes0Juliana Romano Lopes1Andressa Francielli Bonjorno2João Lucas Bruno Prates3Cauê Benito Scarim4Jean Leandro Dos Santos5School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, BrazilAntiretroviral Therapy (ART) is an effective treatment for human immunodeficiency virus (HIV) which has transformed the highly lethal disease, acquired immunodeficiency syndrome (AIDS), into a chronic and manageable condition. However, better methods need to be developed for enhancing patient access and adherence to therapy and for improving treatment in the long term to reduce adverse effects. From the perspective of drug discovery, one promising strategy is the development of anti-HIV prodrugs. This approach aims to enhance the efficacy and safety of treatment, promoting the development of more appropriate and convenient systems for patients. In this review, we discussed the use of the prodrug approach for HIV antiviral agents and emphasized nucleoside reverse transcriptase inhibitors. We comprehensively described various strategies that are used to enhance factors such as water solubility, bioavailability, pharmacokinetic parameters, permeability across biological membranes, chemical stability, drug delivery to specific sites/organs, and tolerability. These strategies might help researchers conduct better studies in this field. We also reported successful examples from the primary therapeutic classes while discussing the advantages and limitations. In this review, we highlighted the key trends in the application of the prodrug approach for treating HIV/AIDS.https://www.mdpi.com/1999-4915/15/11/2234prodrugsHIVAIDSnucleoside reverse transcriptase inhibitors (NRTIs)codrugsnew drugs |
| spellingShingle | Lívia da Rocha Fernandes Juliana Romano Lopes Andressa Francielli Bonjorno João Lucas Bruno Prates Cauê Benito Scarim Jean Leandro Dos Santos The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors Viruses prodrugs HIV AIDS nucleoside reverse transcriptase inhibitors (NRTIs) codrugs new drugs |
| title | The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors |
| title_full | The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors |
| title_fullStr | The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors |
| title_full_unstemmed | The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors |
| title_short | The Application of Prodrugs as a Tool to Enhance the Properties of Nucleoside Reverse Transcriptase Inhibitors |
| title_sort | application of prodrugs as a tool to enhance the properties of nucleoside reverse transcriptase inhibitors |
| topic | prodrugs HIV AIDS nucleoside reverse transcriptase inhibitors (NRTIs) codrugs new drugs |
| url | https://www.mdpi.com/1999-4915/15/11/2234 |
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