Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis
Abstract Background Chronic hepatitis C (HCV) infection is a leading cause of liver cirrhosis (LC) worldwide with decompensation-related clinical sequelae. Sarcopenia is currently recognized as a fundamental complication of LC owing to various mechanisms. This study aimed to assess the role of anthr...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-06-01
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| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43066-023-00265-9 |
| _version_ | 1797795863059234816 |
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| author | Amany Nabil Abbasy Hoda Mohamed Abdel-Naby Walid Ismail Ellakany |
| author_facet | Amany Nabil Abbasy Hoda Mohamed Abdel-Naby Walid Ismail Ellakany |
| author_sort | Amany Nabil Abbasy |
| collection | DOAJ |
| description | Abstract Background Chronic hepatitis C (HCV) infection is a leading cause of liver cirrhosis (LC) worldwide with decompensation-related clinical sequelae. Sarcopenia is currently recognized as a fundamental complication of LC owing to various mechanisms. This study aimed to assess the role of anthropometric measures of sarcopenia in predicting the outcome of LC as assessed by the Child-Turcotte-Pugh (CTP) grade. Results A cross-sectional study was carried out on 80 patients with HCV-related LC with different CTP grades. The diagnosis of sarcopenia was based on the 2018 definition of sarcopenia according to the European Working Group on Sarcopenia in Older People (EWGSOP). Muscle strength was assessed by hand grip strength (HGS) and lower leg extension strength (LES). Assessment of muscle mass was performed by measuring mid-calf circumference (MCC) and mid-arm muscle circumference (MAMC). HGS varied significantly between the different CTP grades, being highest in CTP grade C. Additionally, the number of patients diagnosed with “definitive sarcopenia” using either HGS/MCC or LES/MCC varied significantly between CTP grades, being highest in CTP grade C. Conclusions HGS is a better predictor of worse outcomes of liver cirrhosis than LES. The combination of MCC and HGS or LES is a potentially promising noninvasive prognostic biomarker of liver disease. |
| first_indexed | 2024-03-13T03:24:25Z |
| format | Article |
| id | doaj.art-9c2745f55f03487a8ffbabd78630ac41 |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-03-13T03:24:25Z |
| publishDate | 2023-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-9c2745f55f03487a8ffbabd78630ac412023-06-25T11:09:29ZengSpringerOpenEgyptian Liver Journal2090-62262023-06-011311910.1186/s43066-023-00265-9Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosisAmany Nabil Abbasy0Hoda Mohamed Abdel-Naby1Walid Ismail Ellakany2Department of Tropical Medicine, Faculty of Medicine, Alexandria UniversityDepartment of Physical Medicine, Faculty of Medicine, Rheumatology, and Rehabilitation, Alexandria UniversityDepartment of Tropical Medicine, Faculty of Medicine, Alexandria UniversityAbstract Background Chronic hepatitis C (HCV) infection is a leading cause of liver cirrhosis (LC) worldwide with decompensation-related clinical sequelae. Sarcopenia is currently recognized as a fundamental complication of LC owing to various mechanisms. This study aimed to assess the role of anthropometric measures of sarcopenia in predicting the outcome of LC as assessed by the Child-Turcotte-Pugh (CTP) grade. Results A cross-sectional study was carried out on 80 patients with HCV-related LC with different CTP grades. The diagnosis of sarcopenia was based on the 2018 definition of sarcopenia according to the European Working Group on Sarcopenia in Older People (EWGSOP). Muscle strength was assessed by hand grip strength (HGS) and lower leg extension strength (LES). Assessment of muscle mass was performed by measuring mid-calf circumference (MCC) and mid-arm muscle circumference (MAMC). HGS varied significantly between the different CTP grades, being highest in CTP grade C. Additionally, the number of patients diagnosed with “definitive sarcopenia” using either HGS/MCC or LES/MCC varied significantly between CTP grades, being highest in CTP grade C. Conclusions HGS is a better predictor of worse outcomes of liver cirrhosis than LES. The combination of MCC and HGS or LES is a potentially promising noninvasive prognostic biomarker of liver disease.https://doi.org/10.1186/s43066-023-00265-9SarcopeniaAnthropometryHCVLiver cirrhosisPrognosisOutcome |
| spellingShingle | Amany Nabil Abbasy Hoda Mohamed Abdel-Naby Walid Ismail Ellakany Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis Egyptian Liver Journal Sarcopenia Anthropometry HCV Liver cirrhosis Prognosis Outcome |
| title | Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis |
| title_full | Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis |
| title_fullStr | Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis |
| title_full_unstemmed | Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis |
| title_short | Prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of Egyptian patients with hepatitis C-induced liver cirrhosis |
| title_sort | prognostic and diagnostic anthropometric biomarkers of sarcopenia in a cohort of egyptian patients with hepatitis c induced liver cirrhosis |
| topic | Sarcopenia Anthropometry HCV Liver cirrhosis Prognosis Outcome |
| url | https://doi.org/10.1186/s43066-023-00265-9 |
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