Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia

Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib‐resistant chronic lymphocytic leukaemia

Ibrutinib exerts promising anticancer effects in chronic lymphocytic leukaemia (CLL). However, acquired resistance occurs during treatment, necessitating the exploration of underlying mechanisms. Although three‐dimensional genome organization has been identified as a major player in the development...

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Bibliographic Details
Main Authors: Zijuan Wu, Luqiao Wang, Lei Fan, Hanning Tang, Xiaoling Zuo, Danling Gu, Xueying Lu, Yue Li, Jiazhu Wu, Shuchao Qin, Yi Xia, Huayuan Zhu, Li Wang, Wei Xu, Jianyong Li, Hui Jin
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Molecular Oncology
Subjects:
chronic lymphocytic leukaemia
ibrutinib resistance
metabolism
PAK1
three‐dimensional genome
Online Access:https://doi.org/10.1002/1878-0261.13281

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