The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity

The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity

The COP9 signalosome inhibits the activity of Cullin-RING E3 ubiquitin ligases by removing Nedd8 modifications from their Cullin subunits. Neddylation renders these complexes catalytically active, but deneddylation is also necessary for them to exchange adaptor subunits and avoid auto-ubiquitination...

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Bibliographic Details
Main Authors: Annabelle Suisse, Miklós Békés, Tony T. Huang, Jessica E. Treisman
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:Fly
Subjects:
cop9 signalosome
cullin
wing disc
nedd8
ubiquitin ligase
Online Access:http://dx.doi.org/10.1080/19336934.2018.1429858

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