Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions
Several epidemiological studies support low cancer rates in patients with neurodegenerative disorders, including Parkinson's disease, Huntington's disease, and Alzheimer's disease. Different mechanisms were raised as possible causes, from mutated tumor suppressor genes (PARKIN, PINK1)...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-03-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1585708670181-466585019.pdf |
| _version_ | 1818466266422181888 |
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| author | Natalia González Rojas, Martin Cesarini, José Luis Etcheverry, Gustavo Andrés Da Prat, Valeria Antico Arciuch, Emilia Mabel Gatto |
| author_facet | Natalia González Rojas, Martin Cesarini, José Luis Etcheverry, Gustavo Andrés Da Prat, Valeria Antico Arciuch, Emilia Mabel Gatto |
| author_sort | Natalia González Rojas, Martin Cesarini, José Luis Etcheverry, Gustavo Andrés Da Prat, Valeria Antico Arciuch, Emilia Mabel Gatto |
| collection | DOAJ |
| description | Several epidemiological studies support low cancer rates in patients with neurodegenerative disorders, including Parkinson's disease, Huntington's disease, and Alzheimer's disease. Different mechanisms were raised as possible causes, from mutated tumor suppressor genes (PARKIN, PINK1) to small interfering RNA based on the CAG trinucleotide repeat expansions located in introns or untranslated regions. However, as every rule has an exception, some tumors have an increased incidence in these neurodegenerative diseases such as breast and skin cancer (melanoma). This mini-review aims to establish the epidemiology between these neurodegenerative disorders and cancer to determine the possible mechanisms involved and therefore set eventual therapeutic applications. According to our findings, we conclude the presence of an inverse relationship among most cancers and the aforementioned neurodegenerative disorders. However, this concept needs to be considered cautiously considering specific genetic and extra-genetic linkage factors for particular tumors. |
| first_indexed | 2024-04-13T20:56:30Z |
| format | Article |
| id | doaj.art-9c29b0802fd849efaa9cd63a1e283bfe |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-04-13T20:56:30Z |
| publishDate | 2020-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-9c29b0802fd849efaa9cd63a1e283bfe2022-12-22T02:30:18ZengIMR PressJournal of Integrative Neuroscience1757-448X2020-03-0119118719910.31083/j.jin.2020.01.3Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactionsNatalia González Rojas, Martin Cesarini, José Luis Etcheverry, Gustavo Andrés Da Prat, Valeria Antico Arciuch, Emilia Mabel Gatto01 Instituto Neurociencias Buenos Aires (INEBA), Guardia Vieja 4435, CABA, Argentina;2 Sanatorio de la Trinidad Mitre, Bartolomé Mitre 2553, CABA, Argentina;3 Conicet, Godoy Cruz 2290, CABA, ArgentinaSeveral epidemiological studies support low cancer rates in patients with neurodegenerative disorders, including Parkinson's disease, Huntington's disease, and Alzheimer's disease. Different mechanisms were raised as possible causes, from mutated tumor suppressor genes (PARKIN, PINK1) to small interfering RNA based on the CAG trinucleotide repeat expansions located in introns or untranslated regions. However, as every rule has an exception, some tumors have an increased incidence in these neurodegenerative diseases such as breast and skin cancer (melanoma). This mini-review aims to establish the epidemiology between these neurodegenerative disorders and cancer to determine the possible mechanisms involved and therefore set eventual therapeutic applications. According to our findings, we conclude the presence of an inverse relationship among most cancers and the aforementioned neurodegenerative disorders. However, this concept needs to be considered cautiously considering specific genetic and extra-genetic linkage factors for particular tumors.https://jin.imrpress.com/fileup/1757-448X/PDF/1585708670181-466585019.pdf|parkinson's disease|huntington's disease|alzheimer's disease|neurodegenerative disorders|cancer|mechanisms |
| spellingShingle | Natalia González Rojas, Martin Cesarini, José Luis Etcheverry, Gustavo Andrés Da Prat, Valeria Antico Arciuch, Emilia Mabel Gatto Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions Journal of Integrative Neuroscience |parkinson's disease|huntington's disease|alzheimer's disease|neurodegenerative disorders|cancer|mechanisms |
| title | Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions |
| title_full | Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions |
| title_fullStr | Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions |
| title_full_unstemmed | Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions |
| title_short | Neurodegenerative diseases and cancer: sharing common mechanisms in complex interactions |
| title_sort | neurodegenerative diseases and cancer sharing common mechanisms in complex interactions |
| topic | |parkinson's disease|huntington's disease|alzheimer's disease|neurodegenerative disorders|cancer|mechanisms |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1585708670181-466585019.pdf |
| work_keys_str_mv | AT nataliagonzalezrojasmartincesarinijoseluisetcheverrygustavoandresdapratvaleriaanticoarciuchemiliamabelgatto neurodegenerativediseasesandcancersharingcommonmechanismsincomplexinteractions |