Macleaya cordata isoquinoline alkaloids attenuate Escherichia coli lipopolysaccharide-induced intestinal epithelium injury in broiler chickens by co-regulating the TLR4/MyD88/NF-κB and Nrf2 signaling pathways

Macleaya cordata isoquinoline alkaloids attenuate Escherichia coli lipopolysaccharide-induced intestinal epithelium injury in broiler chickens by co-regulating the TLR4/MyD88/NF-κB and Nrf2 signaling pathways

This study sought to explore the effects and potential mechanisms of dietary supplementation with isoquinoline alkaloids (IA) from Macleaya cordata to alleviate lipopolysaccharide (LPS)-induced intestinal epithelium injury in broilers. A total of 486 1-day-old broilers were assigned at random to a c...

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Bibliographic Details
Main Authors: Yang Liu, Kai Han, Hua Liu, Gang Jia, Luke Comer, Guanlin Wang, Zizhu Pan, Yiqian Zhao, Shuzhen Jiang, Ning Jiao, Libo Huang, Weiren Yang, Yang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
broiler
Macleaya cordata isoquinoline alkaloid
intestinal epithelium injury
lipopolysaccharide
intestinal inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1335359/full

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