Association of severity of COPD with IgE and interleukin-1beta
Background. Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease characterised by airflow limitation. The role of various inflammatory mediators such as interleukin-1beta (IL-1β) and Immunoglobulin E (IgE) have been implicated in COPD. In present study we aimed to establi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-01-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/303 |
| _version_ | 1819169385209659392 |
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| author | B. Singh S. Arora V. Khanna |
| author_facet | B. Singh S. Arora V. Khanna |
| author_sort | B. Singh |
| collection | DOAJ |
| description | Background. Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease characterised by airflow limitation. The role of various inflammatory mediators such as interleukin-1beta (IL-1β) and Immunoglobulin E (IgE) have been implicated in COPD. In present study we aimed to establish if there is an association between the serum levels of IL-1β and IgE and the severity of airway obstruction. Materials and methods. The study group comprised of 30 non atopic smokers, suffering from COPD and 30 non smoker, healthy controls. Serum levels of IgE and IL-1β were assayed by ELISA in all subjects along with their pulmonary function tests. Results. Serum IgE and IL-1β levels were significantly raised in COPD patients as compared to healthy controls. IL-1β was negatively correlated with FEV1 (r=-0.624, p=0.003) and IgE showed a negative correlation with FVC (r=-0.477, p=0.034). Conclusion. Our study suggests that in COPD IL-1β and IgE serum levels correlate with clinical aspects of disease severity. We suggest that the production of IgE and IL-1β in the airways of patients with COPD may be related to smoking which affects airway obstruction. |
| first_indexed | 2024-12-22T19:18:39Z |
| format | Article |
| id | doaj.art-9c2ac03834874c2dab0661805b4ad168 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-22T19:18:39Z |
| publishDate | 2016-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-9c2ac03834874c2dab0661805b4ad1682022-12-21T18:15:26ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642016-01-0173210.4081/monaldi.2010.303Association of severity of COPD with IgE and interleukin-1betaB. Singh0S. Arora1V. Khanna2Department of Biochemistry, GB Pant Hospital, Government of National Capital Territory, DelhiDepartment of Biochemistry, Lady Hardinge Medical College, Government of National Capital Territory, DelhiDepartment of Medicine, Health care centre, Government of National Capital Territory, DelhiBackground. Chronic obstructive pulmonary disease (COPD) is a pulmonary inflammatory disease characterised by airflow limitation. The role of various inflammatory mediators such as interleukin-1beta (IL-1β) and Immunoglobulin E (IgE) have been implicated in COPD. In present study we aimed to establish if there is an association between the serum levels of IL-1β and IgE and the severity of airway obstruction. Materials and methods. The study group comprised of 30 non atopic smokers, suffering from COPD and 30 non smoker, healthy controls. Serum levels of IgE and IL-1β were assayed by ELISA in all subjects along with their pulmonary function tests. Results. Serum IgE and IL-1β levels were significantly raised in COPD patients as compared to healthy controls. IL-1β was negatively correlated with FEV1 (r=-0.624, p=0.003) and IgE showed a negative correlation with FVC (r=-0.477, p=0.034). Conclusion. Our study suggests that in COPD IL-1β and IgE serum levels correlate with clinical aspects of disease severity. We suggest that the production of IgE and IL-1β in the airways of patients with COPD may be related to smoking which affects airway obstruction.https://www.monaldi-archives.org/index.php/macd/article/view/303IgEIL-1 betaCytokinesPro inflammatorySmokingAirways |
| spellingShingle | B. Singh S. Arora V. Khanna Association of severity of COPD with IgE and interleukin-1beta Monaldi Archives for Chest Disease IgE IL-1 beta Cytokines Pro inflammatory Smoking Airways |
| title | Association of severity of COPD with IgE and interleukin-1beta |
| title_full | Association of severity of COPD with IgE and interleukin-1beta |
| title_fullStr | Association of severity of COPD with IgE and interleukin-1beta |
| title_full_unstemmed | Association of severity of COPD with IgE and interleukin-1beta |
| title_short | Association of severity of COPD with IgE and interleukin-1beta |
| title_sort | association of severity of copd with ige and interleukin 1beta |
| topic | IgE IL-1 beta Cytokines Pro inflammatory Smoking Airways |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/303 |
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