A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus
Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to t...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/1999-4915/13/11/2206 |
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| author | Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu |
| author_facet | Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu |
| author_sort | Jian-Wei Shao |
| collection | DOAJ |
| description | Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or persistent infections in cattle. BovHepVs are distributed worldwide and classified into two genotypes with seven subtypes in genotype 1. In this study, three BovHepV strains were identified in the samples of ticks sucking blood on cattle in the Guangdong province of China, through unbiased high-throughput sequencing. Genetic analysis revealed the polyprotein-coding gene of these viral sequences herein shared 67.7–84.8% nt identity and 76.1–95.6% aa identity with other BovHepVs identified worldwide. As per the demarcation criteria adopted for the genotyping and subtyping of HCV, these three BovHepV strains belonged to a novel subtype within the genotype 1. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of BovHepV, and genetic recombination was not common among BovHepVs. These results expand the knowledge about the genetic diversity and evolution of BovHepV distributed globally, and also indicate genetically divergent BovHepV strains were co-circulating in cattle populations in China. |
| first_indexed | 2024-03-10T04:59:22Z |
| format | Article |
| id | doaj.art-9c2b4105f5d3461a95aa0a7a0f36da43 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:59:22Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9c2b4105f5d3461a95aa0a7a0f36da432023-11-23T01:56:42ZengMDPI AGViruses1999-49152021-11-011311220610.3390/v13112206A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine HepacivirusJian-Wei Shao0Luan-Ying Guo1Yao-Xian Yuan2Jun Ma3Ji-Ming Chen4Quan Liu5School of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaSchool of Life Sciences and Engineering, Foshan University, Foshan 528225, ChinaHepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus <i>Hepacivirus</i> in the family <i>Flaviviridae</i> have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or persistent infections in cattle. BovHepVs are distributed worldwide and classified into two genotypes with seven subtypes in genotype 1. In this study, three BovHepV strains were identified in the samples of ticks sucking blood on cattle in the Guangdong province of China, through unbiased high-throughput sequencing. Genetic analysis revealed the polyprotein-coding gene of these viral sequences herein shared 67.7–84.8% nt identity and 76.1–95.6% aa identity with other BovHepVs identified worldwide. As per the demarcation criteria adopted for the genotyping and subtyping of HCV, these three BovHepV strains belonged to a novel subtype within the genotype 1. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of BovHepV, and genetic recombination was not common among BovHepVs. These results expand the knowledge about the genetic diversity and evolution of BovHepV distributed globally, and also indicate genetically divergent BovHepV strains were co-circulating in cattle populations in China.https://www.mdpi.com/1999-4915/13/11/2206bovine hepacivirusnovel subtypegenetic diversityevolutiontickChina |
| spellingShingle | Jian-Wei Shao Luan-Ying Guo Yao-Xian Yuan Jun Ma Ji-Ming Chen Quan Liu A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus Viruses bovine hepacivirus novel subtype genetic diversity evolution tick China |
| title | A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus |
| title_full | A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus |
| title_fullStr | A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus |
| title_full_unstemmed | A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus |
| title_short | A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus |
| title_sort | novel subtype of bovine hepacivirus identified in ticks reveals the genetic diversity and evolution of bovine hepacivirus |
| topic | bovine hepacivirus novel subtype genetic diversity evolution tick China |
| url | https://www.mdpi.com/1999-4915/13/11/2206 |
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