Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis
Abstract Background Several studies have assessed the relationship between type 2 diabetes (T2D) and tooth loss; however, results have been inconsistent. Therefore, the present systematic review and meta-analysis of observational studies was designed to examine the association between T2D and tooth...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01012-8 |
| _version_ | 1818050388440383488 |
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| author | Amir Reza Ahmadinia Donya Rahebi Masoud Mohammadi Mousa Ghelichi-Ghojogh Alireza Jafari Firooz Esmaielzadeh Abdolhalim Rajabi |
| author_facet | Amir Reza Ahmadinia Donya Rahebi Masoud Mohammadi Mousa Ghelichi-Ghojogh Alireza Jafari Firooz Esmaielzadeh Abdolhalim Rajabi |
| author_sort | Amir Reza Ahmadinia |
| collection | DOAJ |
| description | Abstract Background Several studies have assessed the relationship between type 2 diabetes (T2D) and tooth loss; however, results have been inconsistent. Therefore, the present systematic review and meta-analysis of observational studies was designed to examine the association between T2D and tooth loss. Methods This systematic review and meta-analysis was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guideline. We searched all the relevant studies in international databases of Scopus, PubMed, ProQuest, Web of Science, Cochrane Library, and Google scholar search engine until February 2022. The heterogeneity of the studies was calculated using the I2 index. Measure of effect and 95% confidence interval (CI) were extracted from each study. The results of the study were analyzed using the random effects model. Results In the present study, 22 eligible studies were included. Meta-analysis of unadjusted and adjusted results showed that T2D significantly increased the risk of tooth loss, and Odds Ratio (OR) unadjusted was 1.87 (95% CI: 1.62–2.13, p < 0.001), and OR adjusted was 1.20 (95% CI: 1.10–1.30, p < 0.001), respectively. Subgroup analysis based on study design for adjusted OR indicated that in the cohort study (OR: 1.29, 95% CI: 1.07–1.51), in the cross-sectional study (OR: 1.15, 95% CI: 1.06–1.23), and in the case-control study (OR: 5.10, 95% CI: 1.01–9.18) there was a significant association between T2D and tooth loss. Other subgroups analyses showed consistent results and no publication bias existed. Conclusions The findings suggest that T2D is associated with increased risk of tooth loss. This conclusion may provide useful evidence for correlated clinical researches. |
| first_indexed | 2024-12-10T10:52:41Z |
| format | Article |
| id | doaj.art-9c2b82c4f1f4473fadbd65385d940068 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-10T10:52:41Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-9c2b82c4f1f4473fadbd65385d9400682022-12-22T01:51:57ZengBMCBMC Endocrine Disorders1472-68232022-04-0122112010.1186/s12902-022-01012-8Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysisAmir Reza Ahmadinia0Donya Rahebi1Masoud Mohammadi2Mousa Ghelichi-Ghojogh3Alireza Jafari4Firooz Esmaielzadeh5Abdolhalim Rajabi6Dental Research Center, School of Dentistry Golestan University of Medical SciencesDental Research Center, School of Dentistry Golestan University of Medical SciencesResearch Center of Gastroenterology and Hepatology, Golestan University of Medical SciencesDepartment of Health Management and Social Development Research Center, Golestan University of Medical SciencesDepartment of Health Education and Health Promotion, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical SciencesSchool of Nursing and Allied Medical Sciences, Maragheh University of Medical SciencesDental Research Center, School of Dentistry Golestan University of Medical SciencesAbstract Background Several studies have assessed the relationship between type 2 diabetes (T2D) and tooth loss; however, results have been inconsistent. Therefore, the present systematic review and meta-analysis of observational studies was designed to examine the association between T2D and tooth loss. Methods This systematic review and meta-analysis was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guideline. We searched all the relevant studies in international databases of Scopus, PubMed, ProQuest, Web of Science, Cochrane Library, and Google scholar search engine until February 2022. The heterogeneity of the studies was calculated using the I2 index. Measure of effect and 95% confidence interval (CI) were extracted from each study. The results of the study were analyzed using the random effects model. Results In the present study, 22 eligible studies were included. Meta-analysis of unadjusted and adjusted results showed that T2D significantly increased the risk of tooth loss, and Odds Ratio (OR) unadjusted was 1.87 (95% CI: 1.62–2.13, p < 0.001), and OR adjusted was 1.20 (95% CI: 1.10–1.30, p < 0.001), respectively. Subgroup analysis based on study design for adjusted OR indicated that in the cohort study (OR: 1.29, 95% CI: 1.07–1.51), in the cross-sectional study (OR: 1.15, 95% CI: 1.06–1.23), and in the case-control study (OR: 5.10, 95% CI: 1.01–9.18) there was a significant association between T2D and tooth loss. Other subgroups analyses showed consistent results and no publication bias existed. Conclusions The findings suggest that T2D is associated with increased risk of tooth loss. This conclusion may provide useful evidence for correlated clinical researches.https://doi.org/10.1186/s12902-022-01012-8Type 2 diabetesTooth lossPeriodontitisMeta-analysisEpidemiologic studies |
| spellingShingle | Amir Reza Ahmadinia Donya Rahebi Masoud Mohammadi Mousa Ghelichi-Ghojogh Alireza Jafari Firooz Esmaielzadeh Abdolhalim Rajabi Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis BMC Endocrine Disorders Type 2 diabetes Tooth loss Periodontitis Meta-analysis Epidemiologic studies |
| title | Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis |
| title_full | Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis |
| title_fullStr | Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis |
| title_full_unstemmed | Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis |
| title_short | Association between type 2 diabetes (T2D) and tooth loss: a systematic review and meta-analysis |
| title_sort | association between type 2 diabetes t2d and tooth loss a systematic review and meta analysis |
| topic | Type 2 diabetes Tooth loss Periodontitis Meta-analysis Epidemiologic studies |
| url | https://doi.org/10.1186/s12902-022-01012-8 |
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