Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach
Abstract It has been suggested that Omega‐3 fatty acids may improve endothelial thickness and thereby reduce the onset of cardiovascular diseases such as coronary atherosclerosis and hypertension. However, published observational epidemiological studies on the relationship between cardiovascular dis...
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14782 |
| _version_ | 1797214437652824064 |
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| author | Yuchen Song Qun Wang Lianqun Jia |
| author_facet | Yuchen Song Qun Wang Lianqun Jia |
| author_sort | Yuchen Song |
| collection | DOAJ |
| description | Abstract It has been suggested that Omega‐3 fatty acids may improve endothelial thickness and thereby reduce the onset of cardiovascular diseases such as coronary atherosclerosis and hypertension. However, published observational epidemiological studies on the relationship between cardiovascular disease (CVD) and Omega‐3 fatty acids remain inconclusive. Here, we performed a two‐sample Mendelian randomisation analysis using publicly available GWAS pooled statistics to study a GWAS dataset of 16 380 466 SNPs in 23 363 cases and 195 429 controls (also of European ancestry) to determine genetic susceptibility to hypertension. We performed random‐effects Inverse Variance Weighted (IVW) Mendelian Randomization (MR) analyses supplemented by a series of sensitivity assessments to measure the robustness of the findings and to detect any violations of the MR assumptions. During the course of the study, we used IVW, MR‐Egger, and weighted median regression to infer that Omega‐3 intake has a potentially adverse effect against atherosclerosis, although the trend was not significant (OR = 1.1198; 95%; CI: 0.9641–1.3006, p = .130). Meanwhile, our analyses showed a statistically significant negative association between Omega‐3 fatty acid levels and risk of hypertension (OR = 0.9006; 95% CI: 0.8179–0.9917, p = .033). In addition, we explored the causal relationship between atherosclerosis and hypertension and found a significant correlation (OR = 1.3036; 95% CI: 1.0672–1.5923, p = .009). In conclusion, our extensive data investigated by MR suggest that elevated levels of Omega‐3 fatty acids may be associated with an decreased risk of hypertension. Although there is no direct link between hypertension and atherosclerosis, the possibility of a subtle association cannot be categorically excluded. |
| first_indexed | 2024-04-24T11:14:10Z |
| format | Article |
| id | doaj.art-9c2b87681e4d4af4bdee3f871eb781b1 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-04-24T11:14:10Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-9c2b87681e4d4af4bdee3f871eb781b12024-04-11T11:01:33ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-04-0126438239010.1111/jch.14782Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approachYuchen Song0Qun Wang1Lianqun Jia2College of Integrated Chinese and Western Medicine Liaoning University of Traditional Chinese Medicine Shenyang Liaoning ChinaKey Laboratory of Ministry of Education for TCM Viscera‐State Theory and Applications Ministry of Education of China Liaoning University of Traditional Chinese Medicine Shenyang Liaoning ChinaKey Laboratory of Ministry of Education for TCM Viscera‐State Theory and Applications Ministry of Education of China Liaoning University of Traditional Chinese Medicine Shenyang Liaoning ChinaAbstract It has been suggested that Omega‐3 fatty acids may improve endothelial thickness and thereby reduce the onset of cardiovascular diseases such as coronary atherosclerosis and hypertension. However, published observational epidemiological studies on the relationship between cardiovascular disease (CVD) and Omega‐3 fatty acids remain inconclusive. Here, we performed a two‐sample Mendelian randomisation analysis using publicly available GWAS pooled statistics to study a GWAS dataset of 16 380 466 SNPs in 23 363 cases and 195 429 controls (also of European ancestry) to determine genetic susceptibility to hypertension. We performed random‐effects Inverse Variance Weighted (IVW) Mendelian Randomization (MR) analyses supplemented by a series of sensitivity assessments to measure the robustness of the findings and to detect any violations of the MR assumptions. During the course of the study, we used IVW, MR‐Egger, and weighted median regression to infer that Omega‐3 intake has a potentially adverse effect against atherosclerosis, although the trend was not significant (OR = 1.1198; 95%; CI: 0.9641–1.3006, p = .130). Meanwhile, our analyses showed a statistically significant negative association between Omega‐3 fatty acid levels and risk of hypertension (OR = 0.9006; 95% CI: 0.8179–0.9917, p = .033). In addition, we explored the causal relationship between atherosclerosis and hypertension and found a significant correlation (OR = 1.3036; 95% CI: 1.0672–1.5923, p = .009). In conclusion, our extensive data investigated by MR suggest that elevated levels of Omega‐3 fatty acids may be associated with an decreased risk of hypertension. Although there is no direct link between hypertension and atherosclerosis, the possibility of a subtle association cannot be categorically excluded.https://doi.org/10.1111/jch.14782atherosclerosishypertensionintermediate analysisMendelian randomisationOmega‐3 |
| spellingShingle | Yuchen Song Qun Wang Lianqun Jia Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach The Journal of Clinical Hypertension atherosclerosis hypertension intermediate analysis Mendelian randomisation Omega‐3 |
| title | Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach |
| title_full | Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach |
| title_fullStr | Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach |
| title_full_unstemmed | Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach |
| title_short | Omega‐3 fatty acids and their influence on hypertension and coronary atherosclerosis: Insights from a Mendelian randomization approach |
| title_sort | omega 3 fatty acids and their influence on hypertension and coronary atherosclerosis insights from a mendelian randomization approach |
| topic | atherosclerosis hypertension intermediate analysis Mendelian randomisation Omega‐3 |
| url | https://doi.org/10.1111/jch.14782 |
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