Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases
Abstract Background Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-5217-5 |
| _version_ | 1818858051224993792 |
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| author | Juan Zhao Chunxiu Hu Cheng Wang Wei Yu Yinglu Guo Minghan Shi Yongjie Shui Qichun Wei |
| author_facet | Juan Zhao Chunxiu Hu Cheng Wang Wei Yu Yinglu Guo Minghan Shi Yongjie Shui Qichun Wei |
| author_sort | Juan Zhao |
| collection | DOAJ |
| description | Abstract Background Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its synchronous metastatic lesions in some cases. In this study, we analyzed ER expression concordance between breast cancer primary tumor and metastatic lesions. Methods Paraffin blocks of 100 primary breast invasive ductal carcinoma cases with axillary lymph node metastases were collected. Five tissue cores were punched out from individual primary breast cancer, and one tissue core from each lymph node metastases to assemble tissue microarrays for ER staining. Samples were then scored as 0, 1+, 2+, and 3+ according to the number and intensity of ER stained tumor cells. Results For cases with ER 3+ (strong expression) in all cores of primary lesions (n = 38), ER expression in metastatic lymph node was found in 94.7% of the patients. 91.0% of the metastatic lymph nodes were ER positive, and 84.3% of them to be 3+. Among the 46 cases of ER negative expression in all cores of primary lesions, 39 of them had all the metastatic nodes being ER negative, and ER negative nodes were seen in 95.7% of the metastases. As for 16 cases of ER inconsistent expression in primary lesions, 4 cases showed negative ER expression in all metastatic nodes, 2 cases displayed diffuse consistent ER 3+ expression, and 10 cases displayed variant ER expression. Conclusions The findings suggest that ER expression concordance between breast cancer primary lesion and its matched metastatic lesions could be estimated by primary tumor ER expression pattern. |
| first_indexed | 2024-12-19T08:50:08Z |
| format | Article |
| id | doaj.art-9c2b9daca7ed4b1ba7632c687af76f3d |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-19T08:50:08Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9c2b9daca7ed4b1ba7632c687af76f3d2022-12-21T20:28:44ZengBMCBMC Cancer1471-24072018-12-011811710.1186/s12885-018-5217-5Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastasesJuan Zhao0Chunxiu Hu1Cheng Wang2Wei Yu3Yinglu Guo4Minghan Shi5Yongjie Shui6Qichun Wei7Department of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Pathology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine)Department of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Radiation Oncology, the Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Background Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based on the primary tumor. However, ER expression in breast cancer primary lesion may not match with its synchronous metastatic lesions in some cases. In this study, we analyzed ER expression concordance between breast cancer primary tumor and metastatic lesions. Methods Paraffin blocks of 100 primary breast invasive ductal carcinoma cases with axillary lymph node metastases were collected. Five tissue cores were punched out from individual primary breast cancer, and one tissue core from each lymph node metastases to assemble tissue microarrays for ER staining. Samples were then scored as 0, 1+, 2+, and 3+ according to the number and intensity of ER stained tumor cells. Results For cases with ER 3+ (strong expression) in all cores of primary lesions (n = 38), ER expression in metastatic lymph node was found in 94.7% of the patients. 91.0% of the metastatic lymph nodes were ER positive, and 84.3% of them to be 3+. Among the 46 cases of ER negative expression in all cores of primary lesions, 39 of them had all the metastatic nodes being ER negative, and ER negative nodes were seen in 95.7% of the metastases. As for 16 cases of ER inconsistent expression in primary lesions, 4 cases showed negative ER expression in all metastatic nodes, 2 cases displayed diffuse consistent ER 3+ expression, and 10 cases displayed variant ER expression. Conclusions The findings suggest that ER expression concordance between breast cancer primary lesion and its matched metastatic lesions could be estimated by primary tumor ER expression pattern.http://link.springer.com/article/10.1186/s12885-018-5217-5Breast cancerMetastasisEstrogen receptorConcordance |
| spellingShingle | Juan Zhao Chunxiu Hu Cheng Wang Wei Yu Yinglu Guo Minghan Shi Yongjie Shui Qichun Wei Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases BMC Cancer Breast cancer Metastasis Estrogen receptor Concordance |
| title | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| title_full | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| title_fullStr | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| title_full_unstemmed | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| title_short | Breast cancer primary tumor ER expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| title_sort | breast cancer primary tumor er expression pattern predicts its expression concordance in matched synchronous lymph node metastases |
| topic | Breast cancer Metastasis Estrogen receptor Concordance |
| url | http://link.springer.com/article/10.1186/s12885-018-5217-5 |
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