Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract
The technologies used to produce the different dosage forms of propolis can selectively affect the original propolis compounds and their biological activities. The most common type of propolis extract is hydroethanolic. However, there is considerable demand for ethanol-free propolis presentations, i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3510 |
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| author | Andresa Aparecida Berretta Luana Gonçalves Zamarrenho Juliana Arcadepani Correa Jéssica Aparecida De Lima Giovanna Bonfante Borini Sérgio Ricardo Ambrósio Hernane da Silva Barud Jairo Kenupp Bastos David De Jong |
| author_facet | Andresa Aparecida Berretta Luana Gonçalves Zamarrenho Juliana Arcadepani Correa Jéssica Aparecida De Lima Giovanna Bonfante Borini Sérgio Ricardo Ambrósio Hernane da Silva Barud Jairo Kenupp Bastos David De Jong |
| author_sort | Andresa Aparecida Berretta |
| collection | DOAJ |
| description | The technologies used to produce the different dosage forms of propolis can selectively affect the original propolis compounds and their biological activities. The most common type of propolis extract is hydroethanolic. However, there is considerable demand for ethanol-free propolis presentations, including stable powder forms. Three propolis extract formulations were developed and investigated for chemical composition and antioxidant and antimicrobial activity: polar propolis fraction (PPF), soluble propolis dry extract (PSDE), and microencapsulated propolis extract (MPE). The different technologies used to produce the extracts affected their physical appearance, chemical profile, and biological activity. PPF was found to contain mainly caffeic and <i>p</i>-Coumaric acid, while PSDE and MPE showed a chemical fingerprint closer to the original green propolis hydroalcoholic extract used. MPE, a fine powder (40% propolis in gum Arabic), was readily dispersible in water, and had less intense flavor, taste, and color than PSDE. PSDE, a fine powder (80% propolis) in maltodextrin as a carrier, was perfectly water-soluble and could be used in liquid formulations; it is transparent and has a strong bitter taste. PPF, a purified solid with large amounts of caffeic and <i>p</i>-Coumaric acids, had the highest antioxidant and antimicrobial activity, and therefore merits further study. PSDE and MPE had antioxidant and antimicrobial properties and could be used in products tailored to specific needs. |
| first_indexed | 2024-03-11T04:41:42Z |
| format | Article |
| id | doaj.art-9c2cca2fb51548f9b76f17a2b879e47a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:42Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9c2cca2fb51548f9b76f17a2b879e47a2023-11-17T20:40:02ZengMDPI AGMolecules1420-30492023-04-01288351010.3390/molecules28083510Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic ExtractAndresa Aparecida Berretta0Luana Gonçalves Zamarrenho1Juliana Arcadepani Correa2Jéssica Aparecida De Lima3Giovanna Bonfante Borini4Sérgio Ricardo Ambrósio5Hernane da Silva Barud6Jairo Kenupp Bastos7David De Jong8Research, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda., Ribeirão Preto 14020-670, SP, BrazilResearch, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda., Ribeirão Preto 14020-670, SP, BrazilResearch, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda., Ribeirão Preto 14020-670, SP, BrazilResearch, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda., Ribeirão Preto 14020-670, SP, BrazilResearch, Development & Innovation Department, Apis Flora Industrial e Comercial Ltda., Ribeirão Preto 14020-670, SP, BrazilNucleus of Research in Sciences and Technolog, University of Franca, Franca 14404-600, SP, BrazilBiopolymers and Biomaterials Group, University of Araraquara, Araraquara 14801-320, SP, BrazilSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-900, SP, BrazilRibeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, BrazilThe technologies used to produce the different dosage forms of propolis can selectively affect the original propolis compounds and their biological activities. The most common type of propolis extract is hydroethanolic. However, there is considerable demand for ethanol-free propolis presentations, including stable powder forms. Three propolis extract formulations were developed and investigated for chemical composition and antioxidant and antimicrobial activity: polar propolis fraction (PPF), soluble propolis dry extract (PSDE), and microencapsulated propolis extract (MPE). The different technologies used to produce the extracts affected their physical appearance, chemical profile, and biological activity. PPF was found to contain mainly caffeic and <i>p</i>-Coumaric acid, while PSDE and MPE showed a chemical fingerprint closer to the original green propolis hydroalcoholic extract used. MPE, a fine powder (40% propolis in gum Arabic), was readily dispersible in water, and had less intense flavor, taste, and color than PSDE. PSDE, a fine powder (80% propolis) in maltodextrin as a carrier, was perfectly water-soluble and could be used in liquid formulations; it is transparent and has a strong bitter taste. PPF, a purified solid with large amounts of caffeic and <i>p</i>-Coumaric acids, had the highest antioxidant and antimicrobial activity, and therefore merits further study. PSDE and MPE had antioxidant and antimicrobial properties and could be used in products tailored to specific needs.https://www.mdpi.com/1420-3049/28/8/3510Brazilian green propolispurified extractsoluble dry extractmicroencapsulated extractcaffeic acid<i>p</i>-Coumaric acid |
| spellingShingle | Andresa Aparecida Berretta Luana Gonçalves Zamarrenho Juliana Arcadepani Correa Jéssica Aparecida De Lima Giovanna Bonfante Borini Sérgio Ricardo Ambrósio Hernane da Silva Barud Jairo Kenupp Bastos David De Jong Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract Molecules Brazilian green propolis purified extract soluble dry extract microencapsulated extract caffeic acid <i>p</i>-Coumaric acid |
| title | Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract |
| title_full | Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract |
| title_fullStr | Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract |
| title_full_unstemmed | Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract |
| title_short | Development and Characterization of New Green Propolis Extract Formulations as Promising Candidates to Substitute for Green Propolis Hydroalcoholic Extract |
| title_sort | development and characterization of new green propolis extract formulations as promising candidates to substitute for green propolis hydroalcoholic extract |
| topic | Brazilian green propolis purified extract soluble dry extract microencapsulated extract caffeic acid <i>p</i>-Coumaric acid |
| url | https://www.mdpi.com/1420-3049/28/8/3510 |
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