Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction
<i>Background and objectives:</i> In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). <i>Materials and Methods:</i> A total of 36 healthy, pregnant women who...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/55/7/328 |
| _version_ | 1827853916839084032 |
|---|---|
| author | Esra Celik Seyithan Taysi Seyhun Sucu Hasan Ulusal Emin Sevincler Ahmet Celik |
| author_facet | Esra Celik Seyithan Taysi Seyhun Sucu Hasan Ulusal Emin Sevincler Ahmet Celik |
| author_sort | Esra Celik |
| collection | DOAJ |
| description | <i>Background and objectives:</i> In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). <i>Materials and Methods:</i> A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress index (OSI) calculations were carried out at the biochemistry laboratory at Gaziantep University. <i>Results:</i> According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. There was, however, a positive linear correlation between TOS and total thiol levels in the group with IUGR (<i>p</i> = 0.021, r = 0.384), and a positive linear correlation between OSI and total thiol values in the control group (<i>p</i> = 0.049, r = 0.330). In addition, there was a negative correlation between disulfide levels and gestational weeks at birth in the group with IUGR (<i>p</i> = 0.027, r = 0.369). <i>Conclusions:</i> Consequently, there was no significant difference between the control group and the group with pregnancies complicated by idiopathic IUGR in terms of serum oxidant/antioxidant system parameters and U-II levels. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR. |
| first_indexed | 2024-03-12T11:13:51Z |
| format | Article |
| id | doaj.art-9c2d4722a66c4bab8afeac58b6bbbce9 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:13:51Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-9c2d4722a66c4bab8afeac58b6bbbce92023-09-02T02:29:36ZengMDPI AGMedicina1010-660X2019-07-0155732810.3390/medicina55070328medicina55070328Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth RestrictionEsra Celik0Seyithan Taysi1Seyhun Sucu2Hasan Ulusal3Emin Sevincler4Ahmet Celik5Department of Medical Biochemistry, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, TurkeyDepartment of Medical Biochemistry, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, TurkeyDepartment of Obstetrics and Gynecology, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, TurkeyDepartment of Medical Biochemistry, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, TurkeyDepartment of Obstetrics and Gynecology, Gaziantep University Medical Faculty Hospital, 27310 Gaziantep, TurkeyBalıkesir Atatürk State Hospital, 10100 Balıkesir, Turkey<i>Background and objectives:</i> In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). <i>Materials and Methods:</i> A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress index (OSI) calculations were carried out at the biochemistry laboratory at Gaziantep University. <i>Results:</i> According to this study, there was no statistically significant difference between the group with IUGR and the control group of healthy, pregnant women in terms of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, native thiol/total thiol, and U-II values. There was, however, a positive linear correlation between TOS and total thiol levels in the group with IUGR (<i>p</i> = 0.021, r = 0.384), and a positive linear correlation between OSI and total thiol values in the control group (<i>p</i> = 0.049, r = 0.330). In addition, there was a negative correlation between disulfide levels and gestational weeks at birth in the group with IUGR (<i>p</i> = 0.027, r = 0.369). <i>Conclusions:</i> Consequently, there was no significant difference between the control group and the group with pregnancies complicated by idiopathic IUGR in terms of serum oxidant/antioxidant system parameters and U-II levels. It is necessary to conduct more extensive studies evaluating placental, maternal, and fetal oxidative stress in conjunction in order to investigate the role of oxidative stress in IUGR.https://www.mdpi.com/1010-660X/55/7/328intrauterine growth restrictionoxidative stressthiol-disulfideUrotensin 2 |
| spellingShingle | Esra Celik Seyithan Taysi Seyhun Sucu Hasan Ulusal Emin Sevincler Ahmet Celik Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction Medicina intrauterine growth restriction oxidative stress thiol-disulfide Urotensin 2 |
| title | Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction |
| title_full | Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction |
| title_fullStr | Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction |
| title_full_unstemmed | Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction |
| title_short | Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction |
| title_sort | urotensin 2 and oxidative stress levels in maternal serum in pregnancies complicated by intrauterine growth restriction |
| topic | intrauterine growth restriction oxidative stress thiol-disulfide Urotensin 2 |
| url | https://www.mdpi.com/1010-660X/55/7/328 |
| work_keys_str_mv | AT esracelik urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction AT seyithantaysi urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction AT seyhunsucu urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction AT hasanulusal urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction AT eminsevincler urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction AT ahmetcelik urotensin2andoxidativestresslevelsinmaternalseruminpregnanciescomplicatedbyintrauterinegrowthrestriction |